8-Bromophenanthridin-6-ol

Base Information

Chemical Name:8-Bromophenanthridin-6-ol
CAS No.:26689-66-7
Molecular Formula:C13H8 Br N O
Molecular Weight:274.1127
Hs Code.:
NSC Number:109627
DSSTox Substance ID:DTXSID10296497
Nikkaji Number:J3.544.117D
Wikidata:Q82037125

Synonyms:8-bromophenanthridin-6-ol;26689-66-7;NSC109627;SCHEMBL3503005;SCHEMBL20227579;DTXSID10296497;PRZKTRKRIPLYEK-UHFFFAOYSA-N;NSC-109627

Suppliers and Price of 8-Bromophenanthridin-6-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 8-Bromophenanthridin-6-ol

Chemical Property:

Vapor Pressure:0.000115mmHg at 25°C
Boiling Point:336°C at 760 mmHg
Flash Point:157°C
Density:1.568g/cm³
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:272.97893
Heavy Atom Count:16
Complexity:294

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C3=C(C=C(C=C3)Br)C(=O)N2

Technology Process of 8-Bromophenanthridin-6-ol

There total 3 articles about 8-Bromophenanthridin-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 2,5-dibromo-N-phenylbenzamide

: 26689-66-7
8-bromophenanthridin-6(5H)-one

: 8-phenylphenanthridin-6(5H)-one

Guidance literature:: With 1-(2-hydroxyethyl)piperazine; potassium tert-butylate; In 1,3,5-trimethyl-benzene; at 150 ℃; for 24h; Sealed tube; Inert atmosphere;
DOI:10.1021/acs.joc.0c01019

Reference yield:

: 610-71-9
2,5-dibromobenzoic acid

: 26689-66-7
8-bromophenanthridin-6(5H)-one

: 8-phenylphenanthridin-6(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / tetrahydrofuran / Reflux; Inert atmosphere

2: triethylamine; dmap / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere

3: 1-(2-hydroxyethyl)piperazine; potassium tert-butylate / 1,3,5-trimethyl-benzene / 24 h / 150 °C / Sealed tube; Inert atmosphere

With 1-(2-hydroxyethyl)piperazine; dmap; thionyl chloride; potassium tert-butylate; triethylamine; In tetrahydrofuran; dichloromethane; 1,3,5-trimethyl-benzene;
DOI:10.1021/acs.joc.0c01019

Reference yield:

: 59615-13-3
2,5-Dibromobenzoic acid chloride

: 26689-66-7
8-bromophenanthridin-6(5H)-one

: 8-phenylphenanthridin-6(5H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; dmap / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere

2: 1-(2-hydroxyethyl)piperazine; potassium tert-butylate / 1,3,5-trimethyl-benzene / 24 h / 150 °C / Sealed tube; Inert atmosphere

With 1-(2-hydroxyethyl)piperazine; dmap; potassium tert-butylate; triethylamine; In dichloromethane; 1,3,5-trimethyl-benzene;
DOI:10.1021/acs.joc.0c01019