N-(4-Methylphenyl)-2-(tetrahydro-1H-pyrrolizin-7a(5H)-yl)acetamide

Base Information

Chemical Name:N-(4-Methylphenyl)-2-(tetrahydro-1H-pyrrolizin-7a(5H)-yl)acetamide
CAS No.:88069-58-3
Molecular Formula:C₁₆H₂₂N₂O
Molecular Weight:258.363
Hs Code.:
ChEMBL ID:CHEMBL161002
DSSTox Substance ID:DTXSID50529039
Wikidata:Q82399145

Synonyms:88069-58-3;CHEMBL161002;DTXSID50529039;N-(4-Methylphenyl)-2-(tetrahydro-1H-pyrrolizin-7a(5H)-yl)acetamide

Suppliers and Price of N-(4-Methylphenyl)-2-(tetrahydro-1H-pyrrolizin-7a(5H)-yl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-Methylphenyl)-2-(tetrahydro-1H-pyrrolizin-7a(5H)-yl)acetamide

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:258.173213330
Heavy Atom Count:19
Complexity:324

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)NC(=O)CC23CCCN2CCC3

Technology Process of N-(4-Methylphenyl)-2-(tetrahydro-1H-pyrrolizin-7a(5H)-yl)acetamide

There total 2 articles about N-(4-Methylphenyl)-2-(tetrahydro-1H-pyrrolizin-7a(5H)-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-azoniabicyclo[3.3.0]oct-1⁽⁵⁾-ene perchlorate

: 88069-58-3
2-(Tetrahydro-pyrrolizin-7a-yl)-N-p-tolyl-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 5.01 g / ethanol / 8 h / Heating

2: 1.) NaH / 1.) 1,4-dioxane, 100 deg C, 2 h, 2.) 1,4-dioxane, 100 deg C, 2 h

With sodium hydride; In ethanol;
DOI:10.1021/jm00383a005

Reference yield:

: 88069-56-1
ethyl tetrahydro-1H-pyrrolizin-7a(5H)-ylacetate

: 106-49-0,12221-03-3
p-toluidine

: 88069-58-3
2-(Tetrahydro-pyrrolizin-7a-yl)-N-p-tolyl-acetamide

Guidance literature:: With sodium hydride; Multistep reaction; 1.) 1,4-dioxane, 100 deg C, 2 h, 2.) 1,4-dioxane, 100 deg C, 2 h;
DOI:10.1021/jm00383a005