Tetrahydro-1H-pyrrolizine-7a(5H)-acetic acid ethyl ester

Base Information

• Chemical Name: Tetrahydro-1H-pyrrolizine-7a(5H)-acetic acid ethyl ester
• CAS No.: 88069-56-1
• Molecular Formula: C11H19NO2
• Molecular Weight: 197.277
• Hs Code.: 2933998090
• Mol file: 88069-56-1.mol

Synonyms:tetrahydro-1H-Pyrrolizine-7a(5H)-acetic acid ethyl ester

Chemical Property of Tetrahydro-1H-pyrrolizine-7a(5H)-acetic acid ethyl ester

Chemical Property:

• Boiling Point: 252℃
• Flash Point: 89℃
• PSA: 29.54000
• Density: 1.07
• LogP: 1.50590

Purity/Quality:

97% ^*data from raw suppliers

Ethyltetrahydro-1H-pyrrolizine-7a(5H)-acetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tetrahydro-1H-pyrrolizine-7a(5H)-acetic acid ethyl ester

There total 5 articles about Tetrahydro-1H-pyrrolizine-7a(5H)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.6%

γ-(N-2-pyrrolidinonyl)butyric acid (6739-80-6) + ethyl potassium malonate (6148-64-7) → ethyl tetrahydro-1H-pyrrolizin-7a(5H)-ylacetate (88069-56-1)

Guidance literature:

at 80 - 145 ℃; for 14h; Temperature;

Reference yield: 46.0%

1,7-Diiodoheptane-4-one (177719-25-4) + ethyl potassium malonate (6148-64-7) → ethyl tetrahydro-1H-pyrrolizin-7a(5H)-ylacetate (88069-56-1)

Guidance literature:

1,7-Diiodoheptane-4-one; ethyl potassium malonate; With ammonia; In ethanol; at 20 ℃; for 24h;

In ethanol; at 70 ℃; for 2h;

DOI:10.3987/COM-08-11369

Reference yield: 40.0%

methanol (67-56-1) + 1,7-Diiodoheptane-4-one (177719-25-4) + ethyl potassium malonate (6148-64-7) → 5-methoxycarbonylmethyl-1-azabicyclo<3.3.0>octane (78449-76-0) + ethyl tetrahydro-1H-pyrrolizin-7a(5H)-ylacetate (88069-56-1)

Guidance literature:

methanol; 1,7-Diiodoheptane-4-one; ethyl potassium malonate; With ammonia; at 20 ℃; for 24h;

In ethanol; at 70 ℃; for 2h;

DOI:10.3987/COM-08-11369

upstream raw materials:

ethyl potassium malonate

1,7-dichloro-4-heptanone

methanol

1,7-Diiodoheptane-4-one

Downstream raw materials:

N-(2,6-Diethyl-phenyl)-2-(tetrahydro-pyrrolizin-7a-yl)-acetamide

N-(2,5-Dimethyl-phenyl)-2-(tetrahydro-pyrrolizin-7a-yl)-acetamide

N-(2-Methoxy-phenyl)-2-(tetrahydro-pyrrolizin-7a-yl)-acetamide

2-(Tetrahydro-pyrrolizin-7a-yl)-N-p-tolyl-acetamide