Benzomorpholine

Base Information

• Chemical Name: Benzomorpholine
• CAS No.: 5735-53-5
• Molecular Formula: C8H9NO
• Molecular Weight: 135.166
• Hs Code.: 2934999090
• Mol file: 5735-53-5.mol

Synonyms:2,3-Dihydro-1,4-benzoxazine;2,3-Dihydro-4H-1,4-benzoxazine;3,4-Dihydro-2H-1,4-benzoxazine;3,4-Dihydro-2H-benzo[1,4]oxazine;3,4-Dihydro-2H-benzo[b][1,4]oxazine;Benzomorpholine;Phenmorpholine;Phenomorpholine;

Chemical Property of Benzomorpholine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.658
• Boiling Point: 250.6 °C at 760 mmHg
• PKA: 4.37±0.20(Predicted)
• Flash Point: 91 °C
• PSA: 21.26000
• Density: 1.095 g/cm³
• LogP: 1.62890
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility.: Sparingly soluble in water.(0.26 g/L) (25°C),

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,4-Dihydro-2h-1,4-benzoxazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor.

Technology Process of Benzomorpholine

There total 31 articles about Benzomorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)(phenyl)methanone (19202-00-7) → 1,4-benzoxazine (5735-53-5) + benzaldehyde (100-52-7)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In ethyl acetate; benzene; at -40 ℃;

DOI:10.1002/ardp.19823150611

Reference yield: 100.0%

2-(2-aminophenoxy)ethan-1-ol (42876-07-3) → 1,4-benzoxazine (5735-53-5)

Guidance literature:

With [RuCl₂(N-heterocyclic carbene)(bis[2-(diphenylphosphino)ethyl]amine)]; hydrogen; caesium carbonate; In toluene; butan-1-ol; at 120 ℃; for 6h; under 22502.3 Torr; Schlenk technique; Autoclave;

DOI:10.1021/acs.orglett.9b03878

Reference yield: 100.0%

1-(2H-benzo[b][1,4]oxazin-4(3H)-yl)ethanone (70801-52-4) → 1,4-benzoxazine (5735-53-5)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; at -40 ℃; for 1.16667h;

DOI:10.1002/ardp.19823150611

upstream raw materials:

3,4-dihydro-3-oxo-2H-1,4-benzoxazine

1-(2H-benzo[b][1,4]oxazin-4(3H)-yl)ethanone

(2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)(phenyl)methanone

4-acetyl-4H-1,4-benzoxazine

Downstream raw materials:

(3,4-Dihydro-2H-benzo[1,4]oxazin-5-yl)-phenyl-methanone

2-chloro-1-(2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)ethan-1-one

2H-1,4-Benzoxazin-4(3H)-carbonsaeure-4-nitrophenylester

2-(3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Refernces

• 1、 Abhilash, Vishwanathan,Gadakh, Amol V.,Ganesh, Sambasivam,Hegde, Shivaprasad N.,Jacob, Anand,Karthik, C. S.,Lamees, Thundianandi,Mathivanan, Namachivayam,Sathiyanarayanan, Arumugam Murugan. "Chemoselective hydrosilylation of carboxylic acids using a phosphine-free ruthenium complex and phenylsilane". supporting information. . Retrieved 2022/03/01.
• 2、 Fu, Ying,Gao, Shuang,Gao, Ying-Chao,Guo, Ke-Liang,Li, Juan-Juan,Wang, Zi-Wei,Ye, Fei,Zhao, Li-Xia. "Design, synthesis, and bioevaluation of substituted phenyl isoxazole analogues as herbicide safeners". . p. 10550 - 10559. Retrieved 2020/11/05.