Phosphinic acid, methyl[3-methyl-2-[[(4-methylphenyl)sulfonyl]amino]butyl]-, ethyl ester, (2S)-

Base Information

Chemical Name:Phosphinic acid, methyl[3-methyl-2-[[(4-methylphenyl)sulfonyl]amino]butyl]-, ethyl ester, (2S)-
CAS No.:88129-45-7
Molecular Formula:C15H26NO4PS
Molecular Weight:347.416
Hs Code.:
DSSTox Substance ID:DTXSID001117141

Synonyms:DTXSID001117141;88129-45-7;Phosphinic acid, methyl[3-methyl-2-[[(4-methylphenyl)sulfonyl]amino]butyl]-, ethyl ester, (2S)-

Suppliers and Price of Phosphinic acid, methyl[3-methyl-2-[[(4-methylphenyl)sulfonyl]amino]butyl]-, ethyl ester, (2S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Phosphinic acid, methyl[3-methyl-2-[[(4-methylphenyl)sulfonyl]amino]butyl]-, ethyl ester, (2S)-

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:347.13201648
Heavy Atom Count:22
Complexity:478

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOP(=O)(C)CC(C(C)C)NS(=O)(=O)C1=CC=C(C=C1)C

Technology Process of Phosphinic acid, methyl[3-methyl-2-[[(4-methylphenyl)sulfonyl]amino]butyl]-, ethyl ester, (2S)-

There total 3 articles about Phosphinic acid, methyl[3-methyl-2-[[(4-methylphenyl)sulfonyl]amino]butyl]-, ethyl ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: sodium ethyl methylphosphinate

: 142745-25-3
Toluene-4-sulfonic acid (R)-3-methyl-2-(toluene-4-sulfonylamino)-butyl ester

: 88129-45-7
Methyl-[(R)-3-methyl-2-(toluene-4-sulfonylamino)-butyl]-phosphinic acid ethyl ester

Guidance literature:: In tetrahydrofuran; for 3h; Ambient temperature;
DOI:10.1016/S0040-4039(00)88062-4

Reference yield:

: 4276-09-9,473-75-6
(R)-2-amino-3-methylbutanol

: 88129-45-7
Methyl-[(R)-3-methyl-2-(toluene-4-sulfonylamino)-butyl]-phosphinic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / pyridine / 0 °C

2: 83 percent / tetrahydrofuran / 3 h / Ambient temperature

In tetrahydrofuran; pyridine;
DOI:10.1016/S0040-4039(00)88062-4

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 88129-45-7
Methyl-[(R)-3-methyl-2-(toluene-4-sulfonylamino)-butyl]-phosphinic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / pyridine / 0 °C

2: 83 percent / tetrahydrofuran / 3 h / Ambient temperature

In tetrahydrofuran; pyridine;
DOI:10.1016/S0040-4039(00)88062-4