1H-Indol-6-ol, 4-(2-methoxyethenyl)-, 4-methylbenzenesulfonate (ester), (Z)-

Base Information

Chemical Name:1H-Indol-6-ol, 4-(2-methoxyethenyl)-, 4-methylbenzenesulfonate (ester), (Z)-
CAS No.:88132-57-4
Molecular Formula:C18H17NO4S
Molecular Weight:343.403
Hs Code.:

Synonyms:

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Chemical Property of 1H-Indol-6-ol, 4-(2-methoxyethenyl)-, 4-methylbenzenesulfonate (ester), (Z)-

Chemical Property:

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Technology Process of 1H-Indol-6-ol, 4-(2-methoxyethenyl)-, 4-methylbenzenesulfonate (ester), (Z)-

There total 10 articles about 1H-Indol-6-ol, 4-(2-methoxyethenyl)-, 4-methylbenzenesulfonate (ester), (Z)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52090-24-1
methyl 2-methyl-3,5-dinitrobenzoate

: 88132-57-4
(Z)-4-(2-methoxyvinyl)-6-(p-toluenesulfonyloxy)indole

Guidance literature:: Multi-step reaction with 10 steps

1: 60 percent / HCO₂NHEt₃ / 5percent Pd/C / acetonitrile / Heating

2: 70 percent / 48percent HBF₄, tert-butyl nitrite / ethanol / 0.5 h / 0 °C

3: Cu(NO₃)2*3H₂O, Cu₂O, 0.1 N H₂SO₄ / 0.25 h

4: 95 percent / K₂CO₃ / acetone / 3.5 h / Ambient temperature

5: 61 percent / dimethylformamide / 0.67 h / 115 °C

6: 50 percent / H₂ / 5percent Pd/C / benzene / 3 h

7: K₂CO₃ / acetone / 4 h / Ambient temperature

8: LiAlH₄ / tetrahydrofuran / 0 °C

9: 84 percent / MnO₂ / CH₂Cl₂ / 2 h

10: 1.) n-BuLi / 1.) THF, hexane, RT, 0.5 h, 2.) THF, hexane, RT, 0.75 h

With copper(I) oxide; manganese(IV) oxide; lithium aluminium tetrahydride; tetrafluoroboric acid; n-butyllithium; tert.-butylnitrite; sulfuric acid; hydrogen; triethylammonium formate; potassium carbonate; copper(II) nitrate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile; benzene;
DOI:10.1021/jm00369a026

Reference yield:

: 88132-51-8
methyl 5-hydroxy-2-methyl-3-nitrobenzoate

: 88132-57-4
(Z)-4-(2-methoxyvinyl)-6-(p-toluenesulfonyloxy)indole

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / K₂CO₃ / acetone / 3.5 h / Ambient temperature

2: 61 percent / dimethylformamide / 0.67 h / 115 °C

3: 50 percent / H₂ / 5percent Pd/C / benzene / 3 h

4: K₂CO₃ / acetone / 4 h / Ambient temperature

5: LiAlH₄ / tetrahydrofuran / 0 °C

6: 84 percent / MnO₂ / CH₂Cl₂ / 2 h

7: 1.) n-BuLi / 1.) THF, hexane, RT, 0.5 h, 2.) THF, hexane, RT, 0.75 h

With manganese(IV) oxide; lithium aluminium tetrahydride; n-butyllithium; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/jm00369a026

Reference yield:

: 88132-48-3
methyl 5-amino-2-methyl-3-nitrobenzoate

: 88132-57-4
(Z)-4-(2-methoxyvinyl)-6-(p-toluenesulfonyloxy)indole

Guidance literature:: Multi-step reaction with 9 steps

1: 70 percent / 48percent HBF₄, tert-butyl nitrite / ethanol / 0.5 h / 0 °C

2: Cu(NO₃)2*3H₂O, Cu₂O, 0.1 N H₂SO₄ / 0.25 h

3: 95 percent / K₂CO₃ / acetone / 3.5 h / Ambient temperature

4: 61 percent / dimethylformamide / 0.67 h / 115 °C

5: 50 percent / H₂ / 5percent Pd/C / benzene / 3 h

6: K₂CO₃ / acetone / 4 h / Ambient temperature

7: LiAlH₄ / tetrahydrofuran / 0 °C

8: 84 percent / MnO₂ / CH₂Cl₂ / 2 h

9: 1.) n-BuLi / 1.) THF, hexane, RT, 0.5 h, 2.) THF, hexane, RT, 0.75 h

With copper(I) oxide; manganese(IV) oxide; lithium aluminium tetrahydride; tetrafluoroboric acid; n-butyllithium; tert.-butylnitrite; sulfuric acid; hydrogen; potassium carbonate; copper(II) nitrate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/jm00369a026