52090-24-1

Usage

Uses

Used in Dye and Pigment Manufacturing:
2-METHYL-3,5-DINITRO-BENZOIC ACID METHYL ESTER is used as a key intermediate in the production of various dyes and pigments, contributing to the coloration of different materials.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 2-METHYL-3,5-DINITRO-BENZOIC ACID METHYL ESTER is utilized as a chemical building block in the synthesis of certain pharmaceuticals and drugs, playing a crucial role in the development of new medicinal compounds.

InChI:InChI=1/C9H8N2O6/c1-5-7(9(12)17-2)3-6(10(13)14)4-8(5)11(15)16/h3-4H,1-2H3

Upstream product

• 89-71-4 2-Methyl-benzoic acid methyl ester 
• 7697-37-2 nitric acid 
• 28169-46-2 3,5-dinitro-o-toluic acid 
• 77324-87-9 methyl 2-methyl-5-nitrobenzoate 
• 59382-59-1 2-methyl-3-nitro-benzoic acid methyl ester 
• 67-56-1 methanol 
• 39614-85-2 2-methyl-3,5-dinitro-benzoyl chloride 

Downstream Products

• 28169-46-2 3,5-dinitro-o-toluic acid 
• 632628-04-7 methyl 3,5-diamino-2-methylbenzoate 
• 103956-00-9 methyl 6-amino-1H-indole-4-carboxylate 
• 632625-06-0 3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-methanesulfonylaminobenzoic acid 
• 146948-44-9 methyl 3-amino-2-methyl-5-nitrobenzoate 
• 1383422-54-5 methyl 2-methyl-5-[(3-methylbenzoylaminomethyl)amino]-3-nitrobenzoate 
• 88132-50-7 3-carbomethoxy-4-methyl-5-nitrobenzenediazonium fluoroborate 
• 88132-59-6 (Z)-1-p-toluenesulfonyl-4-<2-(di-n-propylamino)vinyl>-6-(p-toluenesulfonyloxy)indole 
• 88132-60-9 1-p-toluenesulfonyl-4-<2-(di-n-propylamino)ethyl>-6-(p-toluenesulfonyloxy)indole 
• 88156-73-4 1-p-toluenesulfonyl-4-carbomethoxy-6-(p-toluenesulfonyloxy)indole 
• 88132-58-5 (Z)-1-p-toluenesulfonyl-4-(2-methoxyvinyl)-6-(p-toluenesulfonyloxy)indole 
• 88132-53-0 3-nitro-4-<2-(dimethylamino)ethenyl>-5-carbomethoxyphenyl p-toluenesulfonate 
• 88132-52-9 3-nitro-4-methyl-5-carbomethoxyphenyl p-toluenesulfonate 
• 88132-54-1 4-carbomethoxy-6-(p-toluenesulfonyloxy)indole 

Relevant academic research and scientific papers

Br?nsted acid-catalyzed chlorination of aromatic carboxylic acids

The chlorination of aromatic carboxylic acids with SOCl2 has been effectively performed by reacting with a Br?nsted acid as the catalyst. Based on this discovery, an efficient catalytic method that is cheaper than traditional catalytic methods was developed. 20 substrates were chlorinated offering excellent yields in a short reaction time. And the SOCl2/Br?nsted acid system has been used in a larger scale preparative reaction. A dual activation mechanism was proposed to prove the irreplaceable system of SOCl2/Br?nsted acid.

5-SULFAMOYL-2-HYDROXYBENZAMIDE DERIVATIVES

The invention is directed to substituted salicylamide derivatives. Specifically, the invention is directed to compounds according to Formula (I): wherein R, R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof. The compounds of the invention are inhibitors of CD73 and can be useful in the treatment of cancer, pre-cancerous syndromes and diseases associated with CD73 inhibition, such as AIDS, the treatment of HIV, autoimmune diseases, infections, atherosclerosis, and ischemia–reperfusion injury. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CD73 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.