2,4'-Difluorobenzophenone

Base Information

• Chemical Name: 2,4'-Difluorobenzophenone
• CAS No.: 342-25-6
• Molecular Formula: C13H8F2O
• Molecular Weight: 218.203
• Hs Code.: 29147000
• European Community (EC) Number: 206-441-7
• UNII: 5YFK8V5BTE
• DSSTox Substance ID: DTXSID40187788
• Nikkaji Number: J193.791J
• Wikidata: Q72462558
• Mol file: 342-25-6.mol

Synonyms:2,4'-Difluorobenzophenone;342-25-6;(2-Fluorophenyl)(4-fluorophenyl)methanone;(2-fluorophenyl)-(4-fluorophenyl)methanone;2',4-difluorobenzophenone;5YFK8V5BTE;EINECS 206-441-7;MFCD00000319;Methanone, (2-fluorophenyl)(4-fluorophenyl)-;EC 206-441-7;24'-Difluorobenzophenone;UNII-5YFK8V5BTE;2,4`-Difluorobenzophenone;2,4/'-Difluorobenzophenone;SCHEMBL896769;LKFIWRPOVFNPKR-UHFFFAOYSA-;DTXSID40187788;AKOS009158787;CS-W014799;PS-7907;SY009663;(2-Fluorophenyl)(4-fluorophenyl)methanone #;D1796;FT-0610090;2,4 inverted exclamation mark -Difluorobenzophenone;W-106744

Chemical Property of 2,4'-Difluorobenzophenone

Chemical Property:

• Appearance/Colour: clear light yellow liquid after melting
• Melting Point: 22-24 °C(lit.)
• Refractive Index: n20/D 1.5689(lit.)
• Boiling Point: 308.6 °C at 760 mmHg
• Flash Point: 126.8 °C
• PSA: 17.07000
• Density: 1.239 g/cm³
• LogP: 3.19580
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform, Methanol
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 218.05432120
• Heavy Atom Count: 16
• Complexity: 246

Purity/Quality:

99% ^*data from raw suppliers

2,4’-Difluorobenzophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-36/38
• Safety Statements: 26-37/39-24/25-37-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)C2=CC=C(C=C2)F)F
• Uses: 2,4’-Difluorobenzophenone is a reactant in the synthesis of EP1 receptor antagonists for the treatment of overactive bladder. Also used in the design and synthesis of thiosemicarbazone cathespin L inhibitors.

Technology Process of 2,4'-Difluorobenzophenone

There total 8 articles about 2,4'-Difluorobenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-fluoroboronic acid (1765-93-1) + 2-Fluorobenzaldehyde (446-52-6) → 2,4'-difluorobenzophenone (342-25-6)

Guidance literature:

With potassium phosphate; palladium diacetate; In water; methyl cyclohexane; for 8h; Solvent; Reflux;

Reference yield: 88.0%

→ 2,4'-difluorobenzophenone (342-25-6)

Guidance literature:

Reference yield: 76.0%

fluorobenzene (462-06-6) + 2-Fluorobenzoyl chloride (393-52-2) → 2,4'-difluorobenzophenone (342-25-6)

Guidance literature:

With bis[N-(trifluoromethylsulfonylimino)]trifluoromethanesulfonic acid; In dichloromethane; for 19h; Reflux; Inert atmosphere;

DOI:10.1016/j.tetlet.2008.11.038

upstream raw materials:

4-flourophenylmagnesium bromide

2-Fluorobenzoyl chloride

fluorobenzene

1,1,1-trichloro-2-(2-fluoro-phenyl)-2-(4-fluoro-phenyl)-ethane

Downstream raw materials:

2,4'-difluorodiphenylmethane

4(5)-<<2-(2-fluorophenyl)-2-(4'-fluorophenyl)>-ethyl>-imidazole

bis(4-fluorophenyl)-2-fluorophenylmethanol

(2-fluorophenyl)-(4-fluorophenyl)phenylmethanol