Chemical Property of 1-(2-Bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
Chemical Property:
- Vapor Pressure:5.05E-07mmHg at 25°C
- Boiling Point:401.6°Cat760mmHg
- Flash Point:196.7°C
- PSA：107.18000
- Density:1.793g/cm3
- LogP:4.37610
- Storage Temp.:-20°C
- Sensitive.:Moisture Sensitive
- Solubility.:Soluble to 100mM in DMSO and to 50mM in ethanol
- XLogP3:2.6
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:2
- Exact Mass:350.98547
- Heavy Atom Count:21
- Complexity:390
- Purity/Quality:
-
99%, *data from raw suppliers
SB 225002 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC=C(C(=C1)NC(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])O)Br
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Description
CXCR2 (IL-8RB) is a seven-transmembrane G protein-coupled receptor whose physiological ligands include IL-8 (CXCL8) and growth related oncogene α (Gro-α; CXCL1). IL-8 and Gro-α are pro-inflammatory CXC chemokines that act as chemoattractants, especially for neutrophils, and promote angiogenesis. SB 225002 is a selective non-peptide inhibitor of CXCR2, inhibiting IL-8 binding to CXCR2 with an IC50 value of 22 nM. SB225002 inhibits neutrophil chemotaxis in response to IL-8 in vitro (IC50 = 20 nM) and blocks neutrophil margination induced by IL-8 in vivo (IC50 = 30 nM). Similarly, SB 225002 reduces neutrophil influx, the production of inflammatory mediators, and tissue damage in TNBS-induced colitis in mice.
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Uses
SB 225002 is a potent and selective CXCR2 antagonist with the ability to inhibit interleukin IL-8 binding to CXCR2.
