N-[(1R)-1-(4-Acetylphenyl)ethyl]acetamide

Base Information

• Chemical Name: N-[(1R)-1-(4-Acetylphenyl)ethyl]acetamide
• CAS No.: 88146-37-6
• Molecular Formula: C12H15NO2
• Molecular Weight: 205.257
• Mol file: 88146-37-6.mol

Synonyms:N-[(1R)-1-(4-Acetylphenyl)ethyl]acetamide;

Chemical Property of N-[(1R)-1-(4-Acetylphenyl)ethyl]acetamide

Chemical Property:

• PSA: 46.17000
• LogP: 2.47720
• Solubility.: Dichloromethane, Methanol

Purity/Quality:

98%Min ^*data from raw suppliers

N-[(1R)-1-(4-Acetylphenyl)ethyl]acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-[(1R)-1-(4-Acetylphenyl)ethyl]acetamide is useful for the preparation of piperazine derivatives as TNF production inhibitors and IL-10 production promoters.

Technology Process of N-[(1R)-1-(4-Acetylphenyl)ethyl]acetamide

There total 3 articles about N-[(1R)-1-(4-Acetylphenyl)ethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-acetyl-1-phenylethylamine (36283-44-0,6284-14-6) + acetyl chloride (75-36-5) → (R)-N-(1-(4-acetylphenyl)ethyl)acetamide (88146-37-6)

Guidance literature:

With aluminum (III) chloride; In 1,2-dichloro-ethane; at 20 - 60 ℃; for 4h;

DOI:10.1039/c1ob05332a

Reference yield:

(R)-1-phenyl-ethyl-amine (3886-69-9) → (R)-N-(1-(4-acetylphenyl)ethyl)acetamide (88146-37-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 0 - 20 °C

2: AlCl₃ / 1,2-dichloro-ethane / 20 °C

With aluminium trichloride; triethylamine; In dichloromethane; 1,2-dichloro-ethane; 1: Acetylation / 2: Friedel-Crafts reaction;

DOI:10.1016/S0960-894X(00)00129-3

Reference yield:

→ (R)-N-(1-(4-acetylphenyl)ethyl)acetamide (88146-37-6)

Guidance literature:

upstream raw materials:

N-acetyl-1-phenylethylamine

acetyl chloride

(R)-1-phenyl-ethyl-amine

Downstream raw materials:

trans-(R)-4-(1-aminoethyl)cyclohexanecarboxylic acid hydrochloride

trans-(R)-4-(1-aminoethyl)cyclohexanecarboxylic acid methyl ester

(1R,4r)-4-((R)-1-((tert-butoxycarbonyl)amino)ethyl)cyclohexanecarboxylic acid

C₁₉H₂₈FN₃O₃