2-(4-Fluorophenyl)-3-(4-methylsulfanylphenyl)thiophene

Base Information

Chemical Name:2-(4-Fluorophenyl)-3-(4-methylsulfanylphenyl)thiophene
CAS No.:88149-83-1
Molecular Formula:C17H13FS2
Molecular Weight:300.421
Hs Code.:
DSSTox Substance ID:DTXSID70442236
Wikidata:Q82259407
Pharos Ligand ID:YLSGLAHB89JV
ChEMBL ID:CHEMBL63286

Synonyms:CHEMBL63286;2-(4-fluorophenyl)-3-(4-methylsulfanylphenyl)thiophene;88149-83-1;SCHEMBL8985431;DTXSID70442236;JDMCOHHLESGGIM-UHFFFAOYSA-N;BDBM50285223;2-(4-fluorophenyl)-3-(4-methylthiophenyl)thiophene;2-(4-fluorophenyl)-3-[4-(methylthio)phenyl]thiophene;2-(4-Fluoro-phenyl)-3-(4-methylsulfanyl-phenyl)-thiophene

Suppliers and Price of 2-(4-Fluorophenyl)-3-(4-methylsulfanylphenyl)thiophene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2-(4-Fluorophenyl)-3-(4-methylsulfanylphenyl)thiophene

Chemical Property:

XLogP3:5.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:300.04427092
Heavy Atom Count:20
Complexity:293

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CSC1=CC=C(C=C1)C2=C(SC=C2)C3=CC=C(C=C3)F

Technology Process of 2-(4-Fluorophenyl)-3-(4-methylsulfanylphenyl)thiophene

There total 5 articles about 2-(4-Fluorophenyl)-3-(4-methylsulfanylphenyl)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 204512-52-7
5-(4-fluorophenyl)-4-[4-(methylthio)phenyl]thiophene-2-carboxylic acid

: 88149-83-1
2-(4-fluorophenyl)-3-[4-(methylthio)phenyl]thiophene

Guidance literature:: With quinoline; copper; for 5h; Heating;
DOI:10.1248/cpb.46.279

Reference yield: 60.0%

: 68-11-1
mercaptoacetic acid

: 204512-50-5
(Z)-3-Chloro-3-(4-fluoro-phenyl)-2-(4-methylsulfanyl-phenyl)-propenal

: 88149-83-1
2-(4-fluorophenyl)-3-[4-(methylthio)phenyl]thiophene

: 204512-52-7
5-(4-fluorophenyl)-4-[4-(methylthio)phenyl]thiophene-2-carboxylic acid

Guidance literature:: With pyridine; triethylamine; 1.) 70 deg C, 1 h, 2.) reflux, 3 h;
DOI:10.1248/cpb.46.279

Reference yield:

: 98546-51-1
(4-thiomethoxyphenyl)boronic acid

: 88149-83-1
2-(4-fluorophenyl)-3-[4-(methylthio)phenyl]thiophene

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / Na₂CO₃, Pd(PPh₃)4 / toluene; ethanol / Heating

2: 80 percent / NBS / CH₂Cl₂; acetic acid / 2 h / Heating

3: 80 percent

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; dichloromethane; acetic acid; toluene;
DOI:10.1016/S0960-894X(96)00513-6