204512-52-7

Upstream product

• 36187-57-2 1-(4-fluorophenyl)-2-(4-(methylthio)phenyl)ethanone 
• 68-11-1 mercaptoacetic acid 
• 204512-50-5 (Z)-3-Chloro-3-(4-fluoro-phenyl)-2-(4-methylsulfanyl-phenyl)-propenal 

Downstream Products

• 88149-83-1 2-(4-fluorophenyl)-3-[4-(methylthio)phenyl]thiophene 
• 140402-91-1 5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-carboxylic acid 
• 140403-87-8 5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-sulfonic acid 
• 140402-47-7 methyl 5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-acetate 
• 140422-80-6 5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-acetic acid 
• 204512-53-8 5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-carbonyl chloride 
• 140402-59-1 5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-carboxamide 
• 140423-22-9 5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-carbonitrile 
• 140402-34-2 5-acetyl-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]thiophene 
• 204512-54-9 N,N-dimethyl-5-(4-fluorophenyl)-4-[4-(methylthio)phenyl]thiophene-2-carboxamide 
• 140403-62-9 N,N-dimethyl-5-(4-fluorophenyl)-4-[4-(methylthio)phenyl]-2-thenylamine 

Relevant academic research and scientific papers

Studies on anti-inflammatory agents. VI. Synthesis and pharmacological properties of 2,3-diarylthiophenes

A series of novel 5-substituted-2,3-diarylthiophenes has been synthesized and found to be active in the rat adjuvant arthritis (AA) model and/or in the yeast-induced hyperalgesia (Randall-Selitto) assay. Among the compounds synthesized herein, 2-(4-fluorophenyl)-3-[4- (methylsulfonyl)phenyl]-S-(trifluoromethyl)thiophene (6a) exhibited the most potent activities on AA, collagen-Induced arthritis (CIA) and the delayed- type hypersensitivity response to type II collagen. 5-Bromo-2-[4- (methylamino)phenyl]-3-[4-(methylsulfinyl)phenyl]thiophene (38) is also a potent inhibitor of AA, CIA, hyperalgesia and in vitro tumor necrosis factor- α production.