2-Pentyn-1-ol, 5-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-

Base Information

Chemical Name:2-Pentyn-1-ol, 5-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-
CAS No.:88159-03-9
Molecular Formula:C21H26O2Si
Molecular Weight:338.522
Hs Code.:
DSSTox Substance ID:DTXSID50444874
Nikkaji Number:J631.445G

Synonyms:2-Pentyn-1-ol, 5-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-;88159-03-9;SCHEMBL13093647;DTXSID50444874;5-(tert-Butyldiphenylsiloxy)-2-pentyne-1-ol

Suppliers and Price of 2-Pentyn-1-ol, 5-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Pentyn-1-ol, 5-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-

Chemical Property:

Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:338.170206602
Heavy Atom Count:24
Complexity:410

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)[Si](C1=CC=CC=C1)(C2=CC=CC=C2)OCCC#CCO

Technology Process of 2-Pentyn-1-ol, 5-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-

There total 10 articles about 2-Pentyn-1-ol, 5-[[(1,1-dimethylethyl)diphenylsilyl]oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 88158-68-3
4-(tert-butyldiphenylsilyloxy)-1-butyne

: 88159-03-9
5-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)pent-2-yn-1-ol

Guidance literature:: 4-(tert-butyldiphenylsilyloxy)-1-butyne; With n-butyllithium; In tetrahydrofuran; at -78 - 0 ℃; for 1h;

formaldehyd; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1016/j.tet.2003.09.070

Reference yield: 92.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 58479-61-1
tert-butylchlorodiphenylsilane

: 88159-03-9
5-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)pent-2-yn-1-ol

Guidance literature:: tert-butylchlorodiphenylsilane; With n-butyllithium; In tetrahydrofuran; pentane; at -78 ℃; for 0.5h; Inert atmosphere;

formaldehyd; In tetrahydrofuran; pentane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol8001333

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 88159-03-9
5-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)pent-2-yn-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 99 percent / imidazole; 4-(dimethylamino)pyridine / CH₂Cl₂ / 16 h / 20 °C

2.1: n-BuLi / diethyl ether; hexane / 1 h / -78 °C

2.2: 72 percent / diethyl ether; hexane / 18 h / 20 °C

With 1H-imidazole; dmap; n-butyllithium; In diethyl ether; hexane; dichloromethane;
DOI:10.1021/ja060064v