1H-Pyrrole-3-carboxaldehyde, 5-phenyl-1-[[4-(trifluoromethyl)phenyl]sulfonyl]-

Base Information

Chemical Name:1H-Pyrrole-3-carboxaldehyde, 5-phenyl-1-[[4-(trifluoromethyl)phenyl]sulfonyl]-
CAS No.:881673-47-8
Molecular Formula:C18H12F3NO3S
Molecular Weight:379.359
Hs Code.:

Synonyms:

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Chemical Property of 1H-Pyrrole-3-carboxaldehyde, 5-phenyl-1-[[4-(trifluoromethyl)phenyl]sulfonyl]-

Chemical Property:

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Technology Process of 1H-Pyrrole-3-carboxaldehyde, 5-phenyl-1-[[4-(trifluoromethyl)phenyl]sulfonyl]-

There total 5 articles about 1H-Pyrrole-3-carboxaldehyde, 5-phenyl-1-[[4-(trifluoromethyl)phenyl]sulfonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 881673-48-9
ethyl 5-phenyl-1-{[4-(trifluoromethyl)phenyl]sulfonyl}-1H-pyrrole-3-carboxylate

: 881673-47-8
5-phenyl-1-{[4-(trifluoromethyl)phenyl]sulfonyl}-1H-pyrrole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.5 h / -78 °C

2: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 1 h / 20 °C / Molecular sieve

With tetrapropylammonium perruthennate; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; toluene; acetonitrile;
DOI:10.1016/j.bmc.2012.04.014

Reference yield:

: 22984-74-3
Ethyl 2-cyano-4-oxo-4-phenylbutanoate

: 881673-47-8
5-phenyl-1-{[4-(trifluoromethyl)phenyl]sulfonyl}-1H-pyrrole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / tetrahydrofuran / 3 h / 20 °C / Cooling with ice

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 24 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

3.2: 1 h / 0 - 20 °C

4.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.5 h / -78 °C

5.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 1 h / 20 °C / Molecular sieve

With hydrogenchloride; tetrapropylammonium perruthennate; palladium 10% on activated carbon; hydrogen; sodium hydride; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;
DOI:10.1016/j.bmc.2012.04.014

Reference yield:

: 70-11-1
α-bromoacetophenone

: 881673-47-8
5-phenyl-1-{[4-(trifluoromethyl)phenyl]sulfonyl}-1H-pyrrole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / 0.75 h / 40 °C

1.2: 18.5 h / 20 °C

2.1: hydrogenchloride / tetrahydrofuran / 3 h / 20 °C / Cooling with ice

3.1: palladium 10% on activated carbon; hydrogen / ethanol / 24 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

4.2: 1 h / 0 - 20 °C

5.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.5 h / -78 °C

6.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 1 h / 20 °C / Molecular sieve

With hydrogenchloride; tetrapropylammonium perruthennate; palladium 10% on activated carbon; hydrogen; sodium hydride; diisobutylaluminium hydride; potassium carbonate; 4-methylmorpholine N-oxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;
DOI:10.1016/j.bmc.2012.04.014