2-(3-Methoxyphenyl)-4,5-dihydro-1,3-oxazole

Base Information

Chemical Name:2-(3-Methoxyphenyl)-4,5-dihydro-1,3-oxazole
CAS No.:88186-32-7
Molecular Formula:C10H11NO2
Molecular Weight:177.203
Hs Code.:
DSSTox Substance ID:DTXSID30521617
Wikidata:Q82386189

Synonyms:88186-32-7;2-(3-Methoxyphenyl)-4,5-dihydro-1,3-oxazole;SCHEMBL8731588;DTXSID30521617

Suppliers and Price of 2-(3-Methoxyphenyl)-4,5-dihydro-1,3-oxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(3-Methoxyphenyl)-4,5-dihydro-1,3-oxazole

Chemical Property:

XLogP3:1.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:177.078978594
Heavy Atom Count:13
Complexity:203

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC(=C1)C2=NCCO2

Technology Process of 2-(3-Methoxyphenyl)-4,5-dihydro-1,3-oxazole

There total 6 articles about 2-(3-Methoxyphenyl)-4,5-dihydro-1,3-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 141-43-5
ethanolamine

: 586-38-9
3-Methoxybenzoic acid

: 88186-32-7
4,5-dihydro-2-(3-methoxyphenyl)oxazole

Guidance literature:: 3-Methoxybenzoic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 23 ℃; for 3h;

ethanolamine; With triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 23 ℃; for 10h;
DOI:10.1002/anie.201508719

Reference yield: 77.0%

: 88186-32-7
4,5-dihydro-2-(3-methoxyphenyl)oxazole

Guidance literature:: With alkali metal carbonate; at 140 ℃; for 24h; Sealed tube;

Reference yield: 63.0%

: N-(2-hydroxyethyl)-3-methoxybenzamide

: 88186-32-7
4,5-dihydro-2-(3-methoxyphenyl)oxazole

Guidance literature:: N-(2-hydroxyethyl)-3-methoxybenzamide; With dmap; triethylamine; p-toluenesulfonyl chloride; In dichloromethane; at 20 ℃;

With sodium hydroxide; In methanol; at 20 ℃;
DOI:10.1021/acs.joc.6b02481