2-chloro-N-cyclopropylbenzamide

Base Information

Chemical Name:2-chloro-N-cyclopropylbenzamide
CAS No.:88229-17-8
Molecular Formula:C10H10ClNO
Molecular Weight:195.648
Hs Code.:
DSSTox Substance ID:DTXSID20395066
Wikidata:Q82194863

Synonyms:2-chloro-N-cyclopropylbenzamide;88229-17-8;Benzamide, 2-chloro-N-cyclopropyl-;SCHEMBL12181561;DTXSID20395066;STK408412;AKOS003249747;F73054;AO-548/11843637;Z32367683

Suppliers and Price of 2-chloro-N-cyclopropylbenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-chloro-N-cyclopropylbenzamide

Chemical Property:

XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:195.0450916
Heavy Atom Count:13
Complexity:203

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC1NC(=O)C2=CC=CC=C2Cl

Technology Process of 2-chloro-N-cyclopropylbenzamide

There total 2 articles about 2-chloro-N-cyclopropylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 609-65-4
o-chlorobenzoyl chloride

: 765-30-0
Cyclopropylamine

: 88229-17-8
(2-chlorobenzoyl)cyclopropylamine

Guidance literature:: In benzene; for 18h;
DOI:10.1021/je00036a040

Reference yield:

: 118-91-2
ortho-chlorobenzoic acid

: 88229-17-8
(2-chlorobenzoyl)cyclopropylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.75 h / 20 °C / Inert atmosphere

2.1: tetrahydrofuran / 0.17 h / Inert atmosphere

2.2: 16 h / 20 °C / Inert atmosphere

With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran;
DOI:10.1016/j.tet.2013.02.080

Reference yield:

: 88229-17-8
(2-chlorobenzoyl)cyclopropylamine

: 16357-33-8
N-(2-chlorobenzyl)-N-cyclopropylamine

Guidance literature:: (2-chlorobenzoyl)cyclopropylamine; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 - 60 ℃; for 3.5h;

With sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃;