N-benzhydryl-2-fluorobenzamide

Base Information

• Chemical Name: N-benzhydryl-2-fluorobenzamide
• CAS No.: 88229-30-5
• Molecular Formula: C20H16FNO
• Molecular Weight: 305.352
• DSSTox Substance ID: DTXSID60357926
• Wikidata: Q82138123
• Mol file: 88229-30-5.mol

Synonyms:N-benzhydryl-2-fluorobenzamide;88229-30-5;Benzamide, N-(diphenylmethyl)-2-fluoro-;Cambridge id 5551467;Oprea1_775723;DTXSID60357926;N-(diphenylmethyl)-2-fluorobenzamide;STK094094;AKOS002952620

Chemical Property of N-benzhydryl-2-fluorobenzamide

Chemical Property:

• XLogP3: 4.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 305.121592296
• Heavy Atom Count: 23
• Complexity: 356

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)NC(=O)C3=CC=CC=C3F

Technology Process of N-benzhydryl-2-fluorobenzamide

There total 4 articles about N-benzhydryl-2-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

→ N-benzhydryl-2-fluorobenzamide (88229-30-5)

Guidance literature:

With manganese(II) bromide; silver(I) acetate; In dichloromethane; at 25 ℃; for 24h; Inert atmosphere; Irradiation;

Reference yield: 74.0%

2-Fluorobenzoyl chloride (393-52-2) + Benzhydrylamine (91-00-9) → N-benzhydryl-2-fluorobenzamide (88229-30-5)

Guidance literature:

With triethylamine; In benzene; for 18h;

DOI:10.1021/je00036a040

Reference yield: 68.0%

Diphenylmethane (101-81-5) + 3-(2-fluorophenyl)-5H-1,4,2-dioxazol-5-one → N-benzhydryl-2-fluorobenzamide (88229-30-5)

Guidance literature:

With iron(III) chloride; silver(I) triflimide; In dichloromethane; at 40 ℃; for 16h; regioselective reaction; Inert atmosphere; Irradiation; Glovebox;

DOI:10.1002/anie.202016234

upstream raw materials:

2-Fluorobenzoyl chloride

Benzhydrylamine

Diphenylmethane

2-fluoro-N-hydroxybenzamide

Refernces

• 1、 Tang, Jing-Jing,Yu, Xiaoqiang,Wang, Yi,Yamamoto, Yoshinori,Bao, Ming. "Interweaving Visible-Light and Iron Catalysis for Nitrene Formation and Transformation with Dioxazolones". supporting information. p. 16426 - 16435. Retrieved 2021/05/13.
• 2、 Agwada. "POTENTIAL CENTRAL NERVOUS SYSTEM ACTIVE AGENTS. 3. SYNTHESIS OF SOME SUBSTITUTED BENZAMIDES AND PHENYLACETAMIDES.". . p. 231 - 235. Retrieved 2007/10/02.