4-Azido-2-phenylpyrimidine

Base Information

• Chemical Name: 4-Azido-2-phenylpyrimidine
• CAS No.: 88236-12-8
• Molecular Formula: C10H7N5
• Molecular Weight: 197.199
• DSSTox Substance ID: DTXSID60523068
• Wikidata: Q82388860

Synonyms:4-Azido-2-phenylpyrimidine;88236-12-8;DTXSID60523068;AKOS024456076;AKOS025153455;2-phenyl-4-(2lambda-1-triazen-2-ynyl)pyrimidine

Chemical Property of 4-Azido-2-phenylpyrimidine

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 197.07014524
• Heavy Atom Count: 15
• Complexity: 242

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NC=CC(=N2)N=[N+]=[N-]

Technology Process of 4-Azido-2-phenylpyrimidine

There total 1 articles about 4-Azido-2-phenylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-chloro-2-phenylpyrimidine (14790-42-2) → 4-azido-2-phenylpyrimidine (88236-12-8)

Guidance literature:

With sodium azide; lithium chloride; In N,N-dimethyl-formamide; for 48h; Ambient temperature;

DOI:10.1007/BF00506884

Reference yield: 95.0%

4-azido-2-phenylpyrimidine (88236-12-8) + acetylacetone (123-54-6,81235-32-7) → 1-[5-Methyl-1-(2-phenyl-pyrimidin-4-yl)-1H-[1,2,3]triazol-4-yl]-ethanone (88627-05-8)

Guidance literature:

With triethylamine; In ethanol; for 8h; Heating;

DOI:10.1007/BF00505770

Reference yield: 89.0%

4-azido-2-phenylpyrimidine (88236-12-8) + dimethyl acetylenedicarboxylate (762-42-5) → 1-(2-Phenyl-pyrimidin-4-yl)-1H-[1,2,3]triazole-4,5-dicarboxylic acid dimethyl ester (88236-18-4)

Guidance literature:

at 140 ℃; for 1.5h;

DOI:10.1007/BF00506884

upstream raw materials:

4-chloro-2-phenylpyrimidine

Downstream raw materials:

[3-(2-Phenyl-pyrimidin-4-yl)-3H-[1,2,3]triazol-4-yl]-methanol

2-Phenyl-4-(5-phenyl-[1,2,3]triazol-1-yl)-pyrimidine

2-Phenyl-4-(4-phenyl-[1,2,3]triazol-1-yl)-pyrimidine

1-(2-Phenyl-pyrimidin-4-yl)-1H-[1,2,3]triazole-4,5-dicarboxylic acid dimethyl ester

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