Technology Process of 3-Pyridinecarboxylic acid, 1,2-dihydro-2-oxo-6-(2-phenylethenyl)-, (Z)-
There total 7 articles about 3-Pyridinecarboxylic acid, 1,2-dihydro-2-oxo-6-(2-phenylethenyl)-, (Z)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1) lithium diisopropylamide / 1) THF, 0 deg C, 2 h, 2) THF, 0 deg C, 2 h, then r.t. overnight
2: 48percent HBr / acetic acid / Heating; overnight
With
hydrogen bromide; lithium diisopropyl amide;
In
acetic acid;
DOI:10.1002/jhet.5570200529
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 100 percent / dimethylformamide / 2.5 h / 55 °C
2: 96 percent / 2-methyl-propan-2-ol / 3.5 h / 70 °C
3: 1) lithium diisopropylamide / 1) THF, -30 deg C, 2.5 h, 2) THF, -30 deg C, 2 h, then to O deg C during 1 h
4: SOCl2, pyridine / tetrahydrofuran / reflux, then stirring overnight
With
pyridine; thionyl chloride; lithium diisopropyl amide;
In
tetrahydrofuran; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1002/jhet.5570200529
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 96 percent / 2-methyl-propan-2-ol / 3.5 h / 70 °C
2: 1) lithium diisopropylamide / 1) THF, -30 deg C, 2.5 h, 2) THF, -30 deg C, 2 h, then to O deg C during 1 h
3: SOCl2, pyridine / tetrahydrofuran / reflux, then stirring overnight
With
pyridine; thionyl chloride; lithium diisopropyl amide;
In
tetrahydrofuran; tert-butyl alcohol;
DOI:10.1002/jhet.5570200529
