1H-Pyrazole-4-carboxylic acid, 1-[4-(aminosulfonyl)phenyl]-3-methyl-5-phenyl-, ethyl ester

Base Information

Chemical Name:1H-Pyrazole-4-carboxylic acid, 1-[4-(aminosulfonyl)phenyl]-3-methyl-5-phenyl-, ethyl ester
CAS No.:88281-53-2
Molecular Formula:C19H19N3O4S
Molecular Weight:385.43700
Hs Code.:

Synonyms:3-Methyl-5-phenyl-1-(4-sulfamoyl-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Pyrazole-4-carboxylic acid, 1-[4-(aminosulfonyl)phenyl]-3-methyl-5-phenyl-, ethyl ester

Chemical Property:

Boiling Point:583.9±60.0 °C(Predicted)
PSA：112.66000
Density:1.34±0.1 g/cm3(Predicted)
LogP:4.45290

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole-4-carboxylic acid, 1-[4-(aminosulfonyl)phenyl]-3-methyl-5-phenyl-, ethyl ester

There total 1 articles about 1H-Pyrazole-4-carboxylic acid, 1-[4-(aminosulfonyl)phenyl]-3-methyl-5-phenyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 569-37-9
ethyl 3-oxo-2-benzoylbutanoate

: 4392-54-5
4-aminosulfonylphenylhydrazine

: 88281-53-2
1-(p-sulfamylphenyl)-3-methyl-5-phenyl-4-ethoxycarbonylpyrazole

Guidance literature:: In ethanol; for 6h;
DOI:10.1002/jps.2600720907

Reference yield: 80.0%

: 88281-53-2
1-(p-sulfamylphenyl)-3-methyl-5-phenyl-4-ethoxycarbonylpyrazole

: 88411-88-5
1-(p-sulfamylphenyl)-3-methyl-5-phenyl-4-carboxypyrazole

Guidance literature:: With potassium hydroxide; In ethanol; for 1h; Heating;
DOI:10.1002/jps.2600720907

Reference yield:

: 88281-53-2
1-(p-sulfamylphenyl)-3-methyl-5-phenyl-4-ethoxycarbonylpyrazole

: C₂₄H₂₆N₄O₅S

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / 2N KOH / ethanol / 1 h / Heating

2: 1.) potassium carbonate / 1) acetone, reflux, 1.5 h; 2) acetone, reflux, overnight

With potassium hydroxide; potassium carbonate; In ethanol;
DOI:10.1002/jps.2600720907