1,4,6-Trimethylquinolin-2(1h)-one

Base Information

Chemical Name:1,4,6-Trimethylquinolin-2(1h)-one
CAS No.:53761-42-5
Molecular Formula:C₁₂H₁₃NO
Molecular Weight:187.241
Hs Code.:
NSC Number:108489
DSSTox Substance ID:DTXSID50296254
Wikidata:Q82036749
Mol file:53761-42-5.mol

Synonyms:1,4,6-trimethylquinolin-2(1h)-one;53761-42-5;NSC108489;SCHEMBL12090570;DTXSID50296254;1,4,6-trimethyl-2(1H)-quinolinone;NSC-108489

Suppliers and Price of 1,4,6-Trimethylquinolin-2(1h)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of 1,4,6-Trimethylquinolin-2(1h)-one

Chemical Property:

Vapor Pressure:0.00195mmHg at 25°C
Boiling Point:291.4°Cat760mmHg
Flash Point:127.5°C
Density:1.092g/cm³
XLogP3:1.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:187.099714038
Heavy Atom Count:14
Complexity:282

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC2=C(C=C1)N(C(=O)C=C2C)C

Technology Process of 1,4,6-Trimethylquinolin-2(1h)-one

There total 5 articles about 1,4,6-Trimethylquinolin-2(1h)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 623-08-5
N-methyl-p-toluidine

: 141-97-9
ethyl acetoacetate

: 53761-42-5
1,4,6-trimethylquinolin-2(1H)-one

Guidance literature:: N-methyl-p-toluidine; ethyl acetoacetate; In acetic acid; at 180 ℃; for 0.75h;

With sulfuric acid; at 95 ℃; for 0.75h;
DOI:10.1007/s00726-010-0492-8

Reference yield:

: 2415-85-2
3-oxo-N-(p-tolyl)butanamide

: 53761-42-5
1,4,6-trimethylquinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 3 h / Acidic conditions

2: potassium carbonate / N,N-dimethyl-formamide

With potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1002/anie.202108503

Reference yield:

: 106-49-0,12221-03-3
p-toluidine

: 53761-42-5
1,4,6-trimethylquinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 24 h / Reflux

2: 3 h / Acidic conditions

3: potassium carbonate / N,N-dimethyl-formamide

With potassium carbonate; In N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.202108503