N-[2-(Chloromethyl)-6-(trifluoromethyl)phenyl]acetamide

Base Information

Chemical Name:N-[2-(Chloromethyl)-6-(trifluoromethyl)phenyl]acetamide
CAS No.:88301-82-0
Molecular Formula:C₁₀H₉ClF₃NO
Molecular Weight:251.636
Hs Code.:
DSSTox Substance ID:DTXSID40537885
Wikidata:Q82413028

Synonyms:N-[2-(Chloromethyl)-6-(trifluoromethyl)phenyl]acetamide;88301-82-0;SCHEMBL10960660;DTXSID40537885;FVRDHOGHLUCNMV-UHFFFAOYSA-N

Suppliers and Price of N-[2-(Chloromethyl)-6-(trifluoromethyl)phenyl]acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-(Chloromethyl)-6-(trifluoromethyl)phenyl]acetamide

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:251.0324761
Heavy Atom Count:16
Complexity:257

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)NC1=C(C=CC=C1C(F)(F)F)CCl

Technology Process of N-[2-(Chloromethyl)-6-(trifluoromethyl)phenyl]acetamide

There total 3 articles about N-[2-(Chloromethyl)-6-(trifluoromethyl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88301-96-6
2-{(methylthio)methyl}-6-(trifluoromethyl)aniline

: 88301-82-0
2'-(Chloromethyl)-6'-(trifluoromethyl)acetanilide

Guidance literature:: Multi-step reaction with 2 steps

1: 86.9 percent / 40percent peracetic acid / CH₂Cl₂ / 0 °C

2: toluene / Heating

With peracetic acid; In dichloromethane; toluene;
DOI:10.1021/jo00198a025

Reference yield:

: 88-17-5
2-(trifluoromethyl)benzenamine

: 88301-82-0
2'-(Chloromethyl)-6'-(trifluoromethyl)acetanilide

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / N-chlorosuccinimide, triethylamine / CH₂Cl₂ / Heating

2: 86.9 percent / 40percent peracetic acid / CH₂Cl₂ / 0 °C

3: toluene / Heating

With peracetic acid; N-chloro-succinimide; triethylamine; In dichloromethane; toluene;
DOI:10.1021/jo00198a025