2-Amino-4-(2-(hydroxy(phenyl)methyl)phenyl)pyrimidine-5-carbonitrile

Base Information

Chemical Name:2-Amino-4-(2-(hydroxy(phenyl)methyl)phenyl)pyrimidine-5-carbonitrile
CAS No.:88302-64-1
Molecular Formula:C₁₈H₁₄N₄O
Molecular Weight:302.335
Hs Code.:
DSSTox Substance ID:DTXSID60521488

Synonyms:88302-64-1;2-Amino-4-(2-(hydroxy(phenyl)methyl)phenyl)pyrimidine-5-carbonitrile;2-Amino-4-{2-[hydroxy(phenyl)methyl]phenyl}pyrimidine-5-carbonitrile;DTXSID60521488

Suppliers and Price of 2-Amino-4-(2-(hydroxy(phenyl)methyl)phenyl)pyrimidine-5-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Amino-4-(2-(hydroxy(phenyl)methyl)phenyl)pyrimidine-5-carbonitrile

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:302.11676108
Heavy Atom Count:23
Complexity:428

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C(C2=CC=CC=C2C3=NC(=NC=C3C#N)N)O

Technology Process of 2-Amino-4-(2-(hydroxy(phenyl)methyl)phenyl)pyrimidine-5-carbonitrile

There total 1 articles about 2-Amino-4-(2-(hydroxy(phenyl)methyl)phenyl)pyrimidine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 124-46-9,20734-13-8,100224-74-6,593-85-1,90332-86-8,3425-08-9
guanidine hydrogen carbonate

: 88302-63-0
3-(2-benzhydrylphenyl)-2-<(dimethylamino)methylene>-3-oxopropanenitrile

: 88302-64-1
2-amino-4-(2-benzhydrylphenyl)pyrimidine-5-carbonitrile

Guidance literature:: With sodium methylate; In methanol; for 18h;
DOI:10.1002/jhet.5570200512

Reference yield:

: 88302-64-1
2-amino-4-(2-benzhydrylphenyl)pyrimidine-5-carbonitrile

: 76988-37-9
7-phenyl-5H-pyrimido<5,4-d><2>benzazepin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / MnO₂ / CH₂Cl₂ / 2 h / Heating

2: 1.) H₂; 2.) MnO₂ / 1.) Raney nickel / 1.) glacial acetic acid, 8.5 h; 2.) methylene dichloride, reflux, 30 min.

With manganese(IV) oxide; hydrogen; nickel; In dichloromethane;
DOI:10.1002/jhet.5570200512