4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-(phenyl methoxy)propyl]-2-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,5R)-

Base Information

• Chemical Name: 4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-(phenyl methoxy)propyl]-2-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,5R)-
• CAS No.: 883441-67-6
• Molecular Formula: C47H52F2N2O5
• Molecular Weight: 762.937

Synonyms:

Chemical Property of 4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-(phenyl methoxy)propyl]-2-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,5R)-

Chemical Property:

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Technology Process of 4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-(phenyl methoxy)propyl]-2-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,5R)-

There total 1 articles about 4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-(phenyl methoxy)propyl]-2-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.7%

(2S,3S)-[2-benzyloxy-3-dibenzylamino-4-(3,5-difluorophenyl)-(R)-1-hydroxymethylbutyl]-((R)-3-benzyloxy-2-hydroxypropyl)-carbamic acid tert-butyl ester → (1S,2S)-5-(R)-[1-benzyloxy-2-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2-(R)-benzyloxymethylmorpholine-4-carboxylic acid tert-butyl ester (883441-67-6)

Guidance literature:

With tributylphosphine; diamide; In benzene; for 1.5h;

Reference yield: 88.3%

(1S,2S)-5-(R)-[1-benzyloxy-2-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2-(R)-benzyloxymethylmorpholine-4-carboxylic acid tert-butyl ester (883441-67-6) → (R)-5-[2-(S)-amino-3-(3,5-difluorophenyl)-1-(S)-hydroxypropyl]-2-(R)-hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester (883441-68-7)

Guidance literature:

With hydrogen; palladium(II) hydroxide/carbon; In ethanol; for 42h; under 760.051 Torr;

Downstream raw materials:

(R)-5-[2-(S)-amino-3-(3,5-difluorophenyl)-1-(S)-hydroxypropyl]-2-(R)-hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester

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