4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-(hydroxy methyl)-, 1,1-dimethylethyl ester, (2R,5R)-

Base Information

• Chemical Name: 4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-(hydroxy methyl)-, 1,1-dimethylethyl ester, (2R,5R)-
• CAS No.: 883441-68-7
• Molecular Formula: C19H28F2N2O5
• Molecular Weight: 402.439

Synonyms:

Chemical Property of 4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-(hydroxy methyl)-, 1,1-dimethylethyl ester, (2R,5R)-

Chemical Property:

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Technology Process of 4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-(hydroxy methyl)-, 1,1-dimethylethyl ester, (2R,5R)-

There total 1 articles about 4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-(hydroxy methyl)-, 1,1-dimethylethyl ester, (2R,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.3%

(1S,2S)-5-(R)-[1-benzyloxy-2-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2-(R)-benzyloxymethylmorpholine-4-carboxylic acid tert-butyl ester (883441-67-6) → (R)-5-[2-(S)-amino-3-(3,5-difluorophenyl)-1-(S)-hydroxypropyl]-2-(R)-hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester (883441-68-7)

Guidance literature:

With hydrogen; palladium(II) hydroxide/carbon; In ethanol; for 42h; under 760.051 Torr;

Reference yield: 68.4%

(R)-5-[2-(S)-amino-3-(3,5-difluorophenyl)-1-(S)-hydroxypropyl]-2-(R)-hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester (883441-68-7) + acetic anhydride (108-24-7) → (R)-5-[2-(S)-acetylamino-3-(3,5-difluorophenyl)-1-(S)-hydroxypropyl]-2-(R)-hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester (883441-64-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.75h;

upstream raw materials:

(1S,2S)-5-(R)-[1-benzyloxy-2-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2-(R)-benzyloxymethylmorpholine-4-carboxylic acid tert-butyl ester

Downstream raw materials:

(R)-5-[2-(S)-acetylamino-3-(3,5-difluorophenyl)-1-(S)-hydroxypropyl]-2-(R)-hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester

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