4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-(acetylamino)-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-(2, 2-dimethylpropoxy)-3-methyl-, 1,1-dimethylethyl ester, (2R,3S,5R)-

Base Information

Chemical Name:4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-(acetylamino)-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-(2, 2-dimethylpropoxy)-3-methyl-, 1,1-dimethylethyl ester, (2R,3S,5R)-
CAS No.:883442-74-8
Molecular Formula:C26H40F2N2O6
Molecular Weight:514.61
Hs Code.:

4-Morpholinecarboxylic acid,
5-[(1S,2S)-2-(acetylamino)-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-(2,
2-dimethylpropoxy)-3-methyl-, 1,1-dimethylethyl ester, (2R,3S,5R)-

Synonyms:

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Chemical Property of 4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-(acetylamino)-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-(2, 2-dimethylpropoxy)-3-methyl-, 1,1-dimethylethyl ester, (2R,3S,5R)-

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

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Technology Process of 4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-(acetylamino)-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-(2, 2-dimethylpropoxy)-3-methyl-, 1,1-dimethylethyl ester, (2R,3S,5R)-

There total 5 articles about 4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-(acetylamino)-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-(2, 2-dimethylpropoxy)-3-methyl-, 1,1-dimethylethyl ester, (2R,3S,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 883442-80-6
(2R,3S,5R)-5-[(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-(2,2-dimethylpropoxy)-3-methylmorpholine-4-carboxylic acid tert-butyl ester

: 108-24-7
acetic anhydride

: 883442-74-8
(2R,3S,5R)-5-[(1S,2S)-2-acetylamino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-(2,2-dimethylpropoxy)-3-methylmorpholine-4-carboxylic acid tert-butyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: (3S,5R)-5-[(1S,2S)-1-benzyloxy-2-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-3-methylmorpholin-2-one

: 883442-74-8
(2R,3S,5R)-5-[(1S,2S)-2-acetylamino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-(2,2-dimethylpropoxy)-3-methylmorpholine-4-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C

2: methanesulfonic acid / 4 h / 50 °C / Molecular sieve

3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 15 h / 75 °C

4: hydrogen; 10 wt% Pd(OH)2 on carbon / ethyl acetate / 760.05 Torr

5: triethylamine / dichloromethane / 20 °C / Inert atmosphere

With methanesulfonic acid; 10 wt% Pd(OH)2 on carbon; hydrogen; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate; 1,2-dichloro-ethane; toluene;
DOI:10.1021/acs.jmedchem.7b01304

Reference yield:

: C₃₂H₃₄F₂N₂O₂*2ClH

: 883442-74-8
(2R,3S,5R)-5-[(1S,2S)-2-acetylamino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-(2,2-dimethylpropoxy)-3-methylmorpholine-4-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 64 h / 20 °C

2: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C

3: methanesulfonic acid / 4 h / 50 °C / Molecular sieve

4: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 15 h / 75 °C

5: hydrogen; 10 wt% Pd(OH)2 on carbon / ethyl acetate / 760.05 Torr

6: triethylamine / dichloromethane / 20 °C / Inert atmosphere

With methanesulfonic acid; 10 wt% Pd(OH)2 on carbon; hydrogen; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate; 1,2-dichloro-ethane; toluene;
DOI:10.1021/acs.jmedchem.7b01304