AcetaMide, N-[(1S,2S)-1-[(3,5-difluorophenyl)Methyl]-2-[(3R,5S,6R)-6-(2,2-diMethylpropoxy)-5-Methyl-3-Morpholinyl]-2-hydroxyethyl]-, (HCl salt)

Base Information

Chemical Name:AcetaMide, N-[(1S,2S)-1-[(3,5-difluorophenyl)Methyl]-2-[(3R,5S,6R)-6-(2,2-diMethylpropoxy)-5-Methyl-3-Morpholinyl]-2-hydroxyethyl]-, (HCl salt)
CAS No.:883446-27-3
Molecular Formula:C₂₁H₃₂F₂N₂O₄*ClH
Molecular Weight:450.954
Hs Code.:
Mol file:883446-27-3.mol

Synonyms:N-[(1S,2S)-3-(3,5-difluorophenyl)-1-[(3R,5S,6R)-6-(2,2-dimethylpropoxy)-5-methylmorpholin-3-yl]-1-hydroxypropan-2-yl]acetamide:hydrochloride;AcetaMide, N-[(1S,2S)-1-[(3,5-difluorophenyl)Methyl]-2-[(3R,5S,6R)-6-(2,2-diMethylpropoxy)-5-Methyl-3-Morpholinyl]-2-hydroxyethyl]-, (HCl salt)

Suppliers and Price of AcetaMide, N-[(1S,2S)-1-[(3,5-difluorophenyl)Methyl]-2-[(3R,5S,6R)-6-(2,2-diMethylpropoxy)-5-Methyl-3-Morpholinyl]-2-hydroxyethyl]-, (HCl salt)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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American Custom Chemicals Corporation
N-[(1S,2S)-1-[(3,5-DIFLUOROPHENYL)METHYL]-2-[(3R,5S,6R)-6-(2,2-DIMETHYLPROPOXY)-5-METHYL-3-MORPHOLINYL]-2-HYDROXYETHYL]ACETAMIDE HYDROCHLORIDE SALT 95.00%
0.1G
$ 1177.00

Total 2 raw suppliers

Chemical Property of AcetaMide, N-[(1S,2S)-1-[(3,5-difluorophenyl)Methyl]-2-[(3R,5S,6R)-6-(2,2-diMethylpropoxy)-5-Methyl-3-Morpholinyl]-2-hydroxyethyl]-, (HCl salt)

Chemical Property:

PSA：83.31000
LogP:4.10970

Purity/Quality:

99% ^*data from raw suppliers

N-[(1S,2S)-1-[(3,5-DIFLUOROPHENYL)METHYL]-2-[(3R,5S,6R)-6-(2,2-DIMETHYLPROPOXY)-5-METHYL-3-MORPHOLINYL]-2-HYDROXYETHYL]ACETAMIDE HYDROCHLORIDE SALT 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of AcetaMide, N-[(1S,2S)-1-[(3,5-difluorophenyl)Methyl]-2-[(3R,5S,6R)-6-(2,2-diMethylpropoxy)-5-Methyl-3-Morpholinyl]-2-hydroxyethyl]-, (HCl salt)

There total 8 articles about AcetaMide, N-[(1S,2S)-1-[(3,5-difluorophenyl)Methyl]-2-[(3R,5S,6R)-6-(2,2-diMethylpropoxy)-5-Methyl-3-Morpholinyl]-2-hydroxyethyl]-, (HCl salt) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 883442-40-8
(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-[(3R,5S,6R)-6-(2,2-dimethylpropoxy)-5-methylmorpholin-3-yl]-propan-1-ol

: 108-24-7
acetic anhydride

: 883446-27-3
N-{(1S,2S)-1-(3,5-Difluorobenzyl)-2-[(3R,5S,6R)-6-(2,2-dimethylpropoxy)-5-methylmorpholin-3-yl]-2-hydroxyethyl}-acetamide hydrochloride

Guidance literature:: (1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-[(3R,5S,6R)-6-(2,2-dimethylpropoxy)-5-methylmorpholin-3-yl]-propan-1-ol; acetic anhydride; In dichloromethane; for 1h;

With hydrogenchloride; In diethyl ether; dichloromethane;

Reference yield:

: 883442-74-8
(2R,3S,5R)-5-[(1S,2S)-2-acetylamino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-(2,2-dimethylpropoxy)-3-methylmorpholine-4-carboxylic acid tert-butyl ester

: 883446-27-3
N-{(1S,2S)-1-(3,5-Difluorobenzyl)-2-[(3R,5S,6R)-6-(2,2-dimethylpropoxy)-5-methylmorpholin-3-yl]-2-hydroxyethyl}-acetamide hydrochloride

Guidance literature:: (2R,3S,5R)-5-[(1S,2S)-2-acetylamino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-(2,2-dimethylpropoxy)-3-methylmorpholine-4-carboxylic acid tert-butyl ester; With trifluoroacetic acid; at 20 ℃;

With hydrogenchloride; In 1,4-dioxane;
DOI:10.1021/acs.jmedchem.7b01304

Reference yield:

: C₃₂H₃₄F₂N₂O₂*2ClH

: 883446-27-3
N-{(1S,2S)-1-(3,5-Difluorobenzyl)-2-[(3R,5S,6R)-6-(2,2-dimethylpropoxy)-5-methylmorpholin-3-yl]-2-hydroxyethyl}-acetamide hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / dichloromethane / 64 h / 20 °C

2: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C

3: methanesulfonic acid / 4 h / 50 °C / Molecular sieve

4: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 15 h / 75 °C

5: hydrogen; 10 wt% Pd(OH)2 on carbon / ethyl acetate / 760.05 Torr

6: triethylamine / dichloromethane / 20 °C / Inert atmosphere

7: trifluoroacetic acid / 20 °C

With methanesulfonic acid; 10 wt% Pd(OH)2 on carbon; hydrogen; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; ethyl acetate; 1,2-dichloro-ethane; toluene;
DOI:10.1021/acs.jmedchem.7b01304