1-[(2R,4S,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimid ine-2,4-dione

Base Information

Chemical Name:1-[(2R,4S,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimid ine-2,4-dione
CAS No.:3545-96-8
Molecular Formula:C₁₀H₁₄N₂O₅
Molecular Weight:242.232
Hs Code.:
Mol file:3545-96-8.mol

Synonyms:1-[(2R,4S,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimid ine-2,4-dione

Suppliers and Price of 1-[(2R,4S,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimid ine-2,4-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[(2R,4S,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimid ine-2,4-dione

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.452g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 1-[(2R,4S,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimid ine-2,4-dione

There total 456 articles about 1-[(2R,4S,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimid ine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: thymidine 3'(4-nitrophenylphosphate)

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

Guidance literature:: With sodium acetate buffer; PDMase; at 37 ℃; for 0.166667h; Rate constant;
DOI:10.1246/bcsj.56.549

Reference yield:

5'-d(AGTAT[5-ethynyl-U]GACCTA)-3': 5'-d(AGTAT[5-ethynyl-U]GACCTA)-3'

: 959326-89-7
2'-deoxycytidine

: 961-07-9
2'-Deoxyguanosine

: 61135-33-9
2'-deoxy-5-ethynyluridine

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

: 958-09-8,7005-15-4
2'-deoxy-D-adenosine

Guidance literature:: With tris hydrochloride; alkaline phosphatase; snake venom phosphodiesterase; at 37 ℃; pH=8.3; Enzymatic reaction;
DOI:10.1002/chem.201001572

Reference yield:

: C₂₃H₃₉N₄O₇P

: C₁₉H₂₅N₃O₁₂P^(1-)

: 365-07-1,15108-71-1,60363-32-8,96744-88-6,132696-16-3,143838-77-1
thymidine 5'-phosphate

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

Guidance literature:: Multi-step reaction with 4 steps

1: tetrazole / acetonitrile / 4 h / 20 °C / Inert atmosphere

2: water; iodine / tetrahydrofuran; acetonitrile / 20 °C

3: hydrazinium monoacetate / methanol; dichloromethane / 2.5 h

4: water; sodium chloride / 72 h / 37 °C / pH 7.5 / Sealed tube; HEPES buffer; Enzymatic reaction

With tetrazole; water; iodine; hydrazinium monoacetate; sodium chloride; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.3390/molecules16010552