3-Methoxy-6-methylbenzene-1,2-diol

Base Information

• Chemical Name: 3-Methoxy-6-methylbenzene-1,2-diol
• CAS No.: 88367-27-5
• Molecular Formula: C₈H₁₀O₃
• Molecular Weight: 154.166
• DSSTox Substance ID: DTXSID60523184
• Nikkaji Number: J2.428.310K
• Wikidata: Q82389131
• Mol file: 88367-27-5.mol

Synonyms:3-Methoxy-6-methylbenzene-1,2-diol;88367-27-5;3-methoxy-6-methyl-1,2-benzenediol;SCHEMBL11796204;DTXSID60523184

Chemical Property of 3-Methoxy-6-methylbenzene-1,2-diol

Chemical Property:

• XLogP3: 1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 154.062994177
• Heavy Atom Count: 11
• Complexity: 127

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(C(=C(C=C1)OC)O)O

Technology Process of 3-Methoxy-6-methylbenzene-1,2-diol

There total 5 articles about 3-Methoxy-6-methylbenzene-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dihydroxy-4-methoxybenzaldehyde (4055-69-0) → 3-Methoxy-6-methylbenzene-1,2-diol (88367-27-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate;

Reference yield:

2,3,4-trihydroxybenzylaldehyde (2144-08-3) + dimethyl sulfate (77-78-1) → 2-methoxy-4-methylbenzene-1,3-diol + 3-Methoxy-6-methylbenzene-1,2-diol (88367-27-5) + 3-Methoxy-4-methyl-benzene-1,2-diol (129627-05-0) + 2,3-dimethoxy-4-methylphenol

Guidance literature:

2,3,4-trihydroxybenzylaldehyde; dimethyl sulfate; With sodium hydroxide; at 80 ℃;

With sodium cyanoborohydride; In tetrahydrofuran; Further byproducts given;

DOI:10.1021/jo061757x

Reference yield:

3-methocycatechol (934-00-9) → 3-Methoxy-6-methylbenzene-1,2-diol (88367-27-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.63 g / aluminium chloride / diethyl ether / 1.5 h / 15 °C / < 15 deg C

2: 490 mg / H₂ / 5percent palladium-charcoal / ethyl acetate

With aluminium trichloride; hydrogen; palladium on activated charcoal; In diethyl ether; ethyl acetate;

upstream raw materials:

2,3-dihydroxy-4-methoxybenzaldehyde

1,2,3-trimethoxy-4-methylbenzene

2,3,4-trihydroxybenzylaldehyde

dimethyl sulfate

Downstream raw materials:

C₈H₉O₆S^(1-)*K⁽¹⁺⁾

C₈H₉O₆S^(1-)*K⁽¹⁺⁾

C₈H₈O₉S₂^(2-)*2K⁽¹⁺⁾

7-hydroxy-6-methoxy-2-methylbenzo[b]furan