3,3-Diphenyl-1-(piperazin-1-yl)propan-1-one

Base Information

• Chemical Name: 3,3-Diphenyl-1-(piperazin-1-yl)propan-1-one
• CAS No.: 88372-34-3
• Molecular Formula: C19H22N2O
• Molecular Weight: 294.396
• DSSTox Substance ID: DTXSID70388701
• Wikidata: Q82183834
• ChEMBL ID: CHEMBL4951820
• Mol file: 88372-34-3.mol

Synonyms:3,3-diphenyl-1-(piperazin-1-yl)propan-1-one;88372-34-3;3,3-diphenyl-1-piperazin-1-ylpropan-1-one;Piperazine, 1-(1-oxo-3,3-diphenylpropyl)-;3,3-diphenyl-1-piperazin-1-yl-propan-1-one;SCHEMBL3831052;CHEMBL4951820;DTXSID70388701;JNALRJOIXRFIQP-UHFFFAOYSA-N;MFCD11583387;AKOS015924592;NS-04954;FT-0738279;C78531;3,3-DIPHENYL-1-(1-PIPERAZINYL)-1-PROPANONE

Chemical Property of 3,3-Diphenyl-1-(piperazin-1-yl)propan-1-one

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 294.173213330
• Heavy Atom Count: 22
• Complexity: 321

Purity/Quality:

99% ^*data from raw suppliers

TERT-BUTYL-4-(3,3-DIPHENYLPROPANOYL)PIPERAZINE-1-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1)C(=O)CC(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 3,3-Diphenyl-1-(piperazin-1-yl)propan-1-one

There total 5 articles about 3,3-Diphenyl-1-(piperazin-1-yl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-(3,3-diphenyl-propionyl)-piperazine-1-carboxylic Acid Tert-butyl Ester (727360-84-1) → 1-(3,3-diphenylpropionyl)piperazine (88372-34-3)

Guidance literature:

4-(3,3-diphenyl-propionyl)-piperazine-1-carboxylic Acid Tert-butyl Ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With sodium hydroxide; In dichloromethane; water;

Reference yield:

3,3-Diphenylpropionic acid (606-83-7) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 1-(3,3-diphenylpropionyl)piperazine (88372-34-3)

Guidance literature:

3,3-Diphenylpropionic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

1-t-Butoxycarbonylpiperazine; With pyridine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

4-(3,3-Diphenyl-propionyl)-piperazine-1-carbaldehyde (143210-47-3) → 1-(3,3-diphenylpropionyl)piperazine (88372-34-3)

Guidance literature:

With hydrogenchloride; In methanol; water; at 100 ℃; Yield given;

DOI:10.1021/jm00100a018

upstream raw materials:

4P₇₈

4-(3,3-Diphenyl-propionyl)-piperazine-1-carbaldehyde

3,3-diphenylpropanoyl chloride

4-(3,3-diphenyl-propionyl)-piperazine-1-carboxylic Acid Tert-butyl Ester

Downstream raw materials:

1,1-diethyl-4-(3,3-diphenyl-propionyl)-piperazinium; iodide

[4-(3,3-Diphenyl-propionyl)-piperazin-1-yl]-thiazol-5-yl-acetonitrile

[4-(3,3-Diphenyl-propionyl)-piperazin-1-yl]-(1-methyl-1H-pyrrol-2-yl)-acetonitrile

3,3-Diphenyl-1-[4-(pyridine-4-carbonyl)-piperazin-1-yl]-propan-1-one