6-Aminophthalide

Base Information

Chemical Name:6-Aminophthalide
CAS No.:57319-65-0
Molecular Formula:C8H7NO2
Molecular Weight:149.149
Hs Code.:2932209090
European Community (EC) Number:260-675-4
NSC Number:49585
UNII:BF6HH4UQR9
DSSTox Substance ID:DTXSID40205936
Nikkaji Number:J349.133A
Wikidata:Q72440998
Mol file:57319-65-0.mol

Synonyms:6-aminophthalide

Suppliers and Price of 6-Aminophthalide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-Aminophthalide
1g
$ 200.00

SynQuest Laboratories
6-Aminophthalide 97%
5 g
$ 264.00

SynQuest Laboratories
6-Aminophthalide 97%
1 g
$ 154.00

SynChem
6-Aminophthalide 95+%
10 g
$ 415.00

SynChem
6-Aminophthalide 95+%
1 g
$ 70.00

SynChem
6-Aminophthalide 95+%
5 g
$ 245.00

Sigma-Aldrich
6-AMINOPHTHALIDE Aldrich
5mg
$ 115.00

Matrix Scientific
6-Amino-2-benzofuran-1(3H)-one 97%
1g
$ 166.00

Matrix Scientific
6-Amino-2-benzofuran-1(3H)-one 97%
10g
$ 1260.00

Crysdot
6-Aminoisobenzofuran-1(3H)-one 95+%
10g
$ 388.00

Total 38 raw suppliers

Chemical Property of 6-Aminophthalide

Chemical Property:

Appearance/Colour:white to light yellow crystal powde
Vapor Pressure:2.87E-07mmHg at 25°C
Melting Point:183 °C
Refractive Index:1.655
Boiling Point:420.2 °C at 760 mmHg
PKA:3.88±0.20(Predicted)
Flash Point:248.3 °C
PSA：52.32000
Density:1.376 g/cm³
LogP:1.52040
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
Water Solubility.:Soluble in water 1360 mg/L 25°C.
XLogP3:0.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:149.047678466
Heavy Atom Count:11
Complexity:181

Purity/Quality:

99%, ^*data from raw suppliers

6-Aminophthalide ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1C2=C(C=C(C=C2)N)C(=O)O1
Uses It is used to produce 6-acetylamino-phthalide. It is also used as a starting material in the reduction reaction. 6-Aminophthalide is used in the total synthesis of uncialamycin and its application to antitumor antibiotics. Also used in permethyl ningalin analogs as P-glycoprotein inhibitors.

Technology Process of 6-Aminophthalide

There total 9 articles about 6-Aminophthalide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 610-93-5
6-nitrophthalide

: 57319-65-0
6-aminophthalide

Guidance literature:: With hydrogen; palladium on activated charcoal;
DOI:10.1039/b508708b

Reference yield: 78.0%

: 610-93-5
6-nitrophthalide

: 10025-69-1
tin(II) chloride dihdyrate

: 57319-65-0
6-aminophthalide

Guidance literature:: In hydrogenchloride; water;

Reference yield:

: 87-41-2
2-benzofuran-1(3H)-one

: 57319-65-0
6-aminophthalide

Guidance literature:: Multi-step reaction with 2 steps

1.1: KNO₃; H₂SO₄

2.1: Fe / acetic acid; ethyl acetate; H₂O / 1 h / Heating

2.2: 86 percent / NaHCO₃ / 0.17 h / Heating

With sulfuric acid; iron; potassium nitrate; In water; acetic acid; ethyl acetate;
DOI:10.1002/jhet.5570430510