Climiqualine

Base Information

• Chemical Name: Climiqualine
• CAS No.: 55150-67-9
• Molecular Formula: C18H12ClN3
• Molecular Weight: 305.761
• Hs Code.: 2933990090
• Mol file: 55150-67-9.mol

Synonyms:3-chloro-1-imidazol-1-yl-4-phenyl-isoquinoline;

Chemical Property of Climiqualine

Chemical Property:

• Vapor Pressure: 2.32E-09mmHg at 25°C
• Boiling Point: 492.4°Cat760mmHg
• Flash Point: 251.6°C
• PSA: 30.71000
• Density: 1.28g/cm³
• LogP: 4.74090

Purity/Quality:

99% ^*data from raw suppliers

CLIMIQUALINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Climiqualine

There total 2 articles about Climiqualine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1H-imidazole (288-32-4) + 1,3-dichloro-4-phenylisoquinoline → climiqualine (55150-67-9)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1016/j.tetlet.2009.04.040

Reference yield:

→ climiqualine (55150-67-9)

Guidance literature:

1,3-Dichlor-4-phenylisochinolin + Imidazol.;

Reference yield: 92.0%

4-methoxyphenylboronic acid (5720-07-0) + climiqualine (55150-67-9) → C25H19N3O (1168136-28-4)

Guidance literature:

With potassium phosphate; dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl; palladium diacetate; In tetrahydrofuran; at 85 ℃;

DOI:10.1016/j.tetlet.2009.04.040

upstream raw materials:

1H-imidazole

Downstream raw materials:

1-(1-Imidazolyl)-4-phenylisoquinoline-oxalate

C₂₅H₁₉N₃O

Refernces

• 1、 -. "Pharmaceutical composition containing 1-(imidazole-1-yl)-isoquinolines and method of treating hyperlipemia". . . Retrieved 2008/06/13.