2-Fluoropyridine-6-carboxylic acid

Base Information

• Chemical Name: 2-Fluoropyridine-6-carboxylic acid
• CAS No.: 402-69-7
• Molecular Formula: C6H4FNO2
• Molecular Weight: 141.102
• Hs Code.: 29333990
• Mol file: 402-69-7.mol

Synonyms:Picolinicacid, 6-fluoro- (8CI);2-Fluoro-6-pyridinecarboxylic acid;6-Fluoropicolinicacid;6-Fluoropyridine-2-carboxylic acid;NSC 16023;

Chemical Property of 2-Fluoropyridine-6-carboxylic acid

Chemical Property:

• Appearance/Colour: White powder
• Vapor Pressure: 1.71mmHg at 25°C
• Melting Point: 139-143 °C(lit.)
• Refractive Index: 1.533
• Boiling Point: 306.3 °C at 760 mmHg
• PKA: 3.30±0.10(Predicted)
• Flash Point: 139 °C
• PSA: 50.19000
• Density: 1.419 g/cm³
• LogP: 0.91890
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

6-Fluoro-2-pyridinecarboxylic Acid >98.0%(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2-Fluoropyridine-6-carboxylic acid

There total 4 articles about 2-Fluoropyridine-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

2-fluoro-6-methylpyridine (407-22-7) → 6-fluoropyridine-2-carboxylic acid (402-69-7)

Guidance literature:

With potassium permanganate; In water; for 3h; Heating / reflux;

Reference yield: 45.0%

2-fluoro-6-methylpyridine (407-22-7) + isopropyl alcohol (67-63-0,8013-70-5) → 6-fluoropyridine-2-carboxylic acid (402-69-7)

Guidance literature:

With potassium permanganate; In chloroform; water;

Reference yield:

2-fluoro-5-methylpyridine (2369-19-9) + water (7732-18-5) → 6-fluoropyridine-2-carboxylic acid (402-69-7)

Guidance literature:

With potassium permanganate; at 100 ℃; for 4h; Heating / reflux;

upstream raw materials:

2-fluoro-6-methylpyridine

2-Amino-6-methylpyridine

2-fluoro-5-methylpyridine

water

Downstream raw materials:

C₃₀H₃₆BFN₄O₇

6-fluoropyridine-2-carbonyl chloride

2-chloro-1-(6-fluoro-2-pyridyl)ethanone

Refernces

• 1、 -. "2-PHENYLPYRIDIN-4-YL DERIVATIVES AS ALK5 INHIBITORS". Page 46-47. . Retrieved 2010/02/06.
• 2、 -. "NOVEL PYRAZOLOPYRIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS". Page 44. . Retrieved 2010/02/06.