2-Amino-6-methylpyridine

Base Information

• Chemical Name: 2-Amino-6-methylpyridine
• CAS No.: 1824-81-3
• Molecular Formula: C6H8N2
• Molecular Weight: 108.143
• Hs Code.: 29333999
• European Community (EC) Number: 217-360-1
• NSC Number: 6971,1488
• UNII: 35ANN6MRBM
• DSSTox Substance ID: DTXSID0044860
• Nikkaji Number: J38.381C
• Wikidata: Q27256454
• Pharos Ligand ID: CYFJ66TK1W6Y
• ChEMBL ID: CHEMBL61591
• Mol file: 1824-81-3.mol

Synonyms:2-Amino-6-methylpyridine;1824-81-3;6-methylpyridin-2-amine;2-Amino-6-picoline;6-Amino-2-picoline;2-Pyridinamine, 6-methyl-;6-Methyl-2-pyridinamine;2-Picoline, 6-amino-;6-Methyl-2-pyridylamine;6-Amino-2-methylpyridine;6-Methyl-2-aminopyridine;NSC 6971;PYRIDINE, 2-AMINO-6-METHYL-;NSC 1488;EINECS 217-360-1;UNII-35ANN6MRBM;35ANN6MRBM;6-methylpyridin-2-ylamine;2-amino-6-methyl pyridine;2-amino-6-methyl-pyridine;6-Methyl-pyridin-2-ylamine;BRN 0107048;CHEMBL61591;AI3-24112;DTXSID0044860;NSC-1488;NSC-6971;WLN: T6NJ BZ F1;5-22-09-00210 (Beilstein Handbook Reference);MFCD00006331;6-aminopicoline;6-Amino picoline;2-amino 6 picoline;2-amino-6methylpyridine;2-amino-6-methylpyridin;6-amino-2-methyl-pyridine;6-methyl-2-amino pyridine;2-Piridinomina, 6-metil-;6-methyl-pyridin-2-yl-amine;SCHEMBL102316;6-methylpyridin-2(1H)-imine;DTXCID8024860;NSC1488;NSC6971;2-Amino-6-methylpyridine, 98%;BCP22085;AMINO-6-METHYLPYRIDINE, 2-;Tox21_300667;BDBM50091794;RB1111;STK301586;STL453503;AKOS000119669;AB00717;AC-7554;CS-W018543;GS-6756;NCGC00248134-01;NCGC00254575-01;CAS-1824-81-3;LS-130245;A0403;AM20050895;FT-0611214;EN300-19899;A23908;Q-101226;Q27256454;F1995-0201;Z104476000;71M

Chemical Property of 2-Amino-6-methylpyridine

Chemical Property:

• Appearance/Colour: yellowish crystalline low melting solid
• Vapor Pressure: 0.213mmHg at 25°C
• Melting Point: 40-44 °C(lit.)
• Refractive Index: 1.574
• Boiling Point: 208.499 °C at 760 mmHg
• PKA: pK1: 7.41(+1) (25°C)
• Flash Point: 103.333 °C
• PSA: 38.91000
• Density: 1.068 g/cm³
• LogP: 1.55340
• Storage Temp.: Store below +30°C.
• Sensitive.: Hygroscopic
• Water Solubility.: very faint turbidity
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 108.068748264
• Heavy Atom Count: 8
• Complexity: 72.9

Purity/Quality:

99% ^*data from raw suppliers

2-?Amino-?6-?methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25-36/37/38-24/25-23/24/25-24
• Safety Statements: 26-36/37/39-45-37/39-28A

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=CC=C1)N
• Uses: Intermediate.

Technology Process of 2-Amino-6-methylpyridine

There total 34 articles about 2-Amino-6-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-amino-6-methylpyridine N-oxide (25063-84-7) → 2-Amino-6-methylpyridine (1824-81-3)

Guidance literature:

With titanium tetrachloride; tin(ll) chloride; In diethyl ether; for 0.5h; Ambient temperature;

Reference yield: 90.0%

→ 2-Amino-6-methylpyridine (1824-81-3)

Guidance literature:

With copper(l) iodide; ammonia; C₁₄H₁₆N₂O₄; caesium carbonate; at 120 ℃; for 24h; Sealed tube; Inert atmosphere;

Reference yield: 88.0%

2-bromo-6-methylpyridine (5315-25-3) → 2-Amino-6-methylpyridine (1824-81-3)

Guidance literature:

With copper(I) oxide; potassium carbonate; ammonium hydroxide; N,N-dimethylethylenediamine; In ethylene glycol; at 60 ℃; for 16h; Inert atmosphere;

DOI:10.1039/b916569j

upstream raw materials:

α-picoline

2-amino-6-methylpyridine N-oxide

2-acetylamino-6-methylpyridine

2-(2,5-dimethyl-1H-pyrrol-1-yl)-6-methylpyridine

Downstream raw materials:

2-(4'-Methylphenyl)-6-methyl-pyrido[1,2-a]pyrimidin-4-one

2-(4'-Fluorophenyl)-6-methyl-pyrido[1,2-a]pyrimidin-4-one

2-(2'-Methoxyphenyl)-6-methyl-pyrido[1,2-a]pyrimidin-4-one

N-(2-amino-6-methyl-pyridinyl)ketoacetamide

Refernces

• 1、 Enamullah, Mohammed,Joy, Baitul Alif,Islam, Mohammad Khairul. "Syntheses, spectroscopy, electrochemistry, EPR, PXRD-structure and DFT/TD-DFT of bis[2-oxo-1-naphthaldehydato-κO,O’]copper(II)". . p. 56 - 64. Retrieved 2019.
• 2、 Madrahimov, Sherzod,Mostafa, Adel,Yempally, Veeranna,Fadlallah, Joelle,AlQaradawi, Siham Y.. "Electronic, infrared, mass spectrometry and thermal studies on the reaction of 2-amino-6-methylpyridine with π-acceptors". . . Retrieved 2020.
• 3、 -. "Method for preparing amino compound by catalytically reducing nitro compound with alkaline earth metal hydride". Paragraph 0074-0077. . Retrieved 2020/09/16.