Benzoic acid, 4-[2-(2,4-diaminopyrido[3,2-d]pyrimidin-6-yl)ethyl]-

Base Information

Chemical Name:Benzoic acid, 4-[2-(2,4-diaminopyrido[3,2-d]pyrimidin-6-yl)ethyl]-
CAS No.:88392-97-6
Molecular Formula:C16H15N5O2
Molecular Weight:309.327
Hs Code.:
DSSTox Substance ID:DTXSID00450228

Synonyms:Benzoic acid, 4-[2-(2,4-diaminopyrido[3,2-d]pyrimidin-6-yl)ethyl]-;88392-97-6;DTXSID00450228

Suppliers and Price of Benzoic acid, 4-[2-(2,4-diaminopyrido[3,2-d]pyrimidin-6-yl)ethyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzoic acid, 4-[2-(2,4-diaminopyrido[3,2-d]pyrimidin-6-yl)ethyl]-

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:309.12257474
Heavy Atom Count:23
Complexity:413

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1CCC2=NC3=C(C=C2)N=C(N=C3N)N)C(=O)O

Technology Process of Benzoic acid, 4-[2-(2,4-diaminopyrido[3,2-d]pyrimidin-6-yl)ethyl]-

There total 11 articles about Benzoic acid, 4-[2-(2,4-diaminopyrido[3,2-d]pyrimidin-6-yl)ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 187242-95-1
4-[2-(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-yl)-ethyl]-benzoic acid butyl ester

: 88392-97-6
2,4-diamino-4-deoxy-8,10-dideazapteroic acid

Guidance literature:: With sodium hydroxide; In methanol; for 72h; Ambient temperature;
DOI:10.1002/jhet.5570330643

Reference yield:

: 88392-93-2
dimethyl 4-amino-4-deoxy-10-carboxy-8,10-dideazapteroate

: 88392-97-6
2,4-diamino-4-deoxy-8,10-dideazapteroic acid

Guidance literature:: With sodium cyanide; In dimethyl sulfoxide; at 175 - 180 ℃; for 2.5h;
DOI:10.1021/jm00369a024

Reference yield:

: 187242-82-6
(E)-4-(3-oxobut-1-en-1-yl)benzoic acid

: 88392-97-6
2,4-diamino-4-deoxy-8,10-dideazapteroic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 62 percent / p-toluenesulphonic acid / 7 h / Heating

2: 53 percent / H₂ / 10percent Pd/C / ethyl acetate / 3 h / 1500.1 Torr / Ambient temperature

3: 72 percent / AcOH / ethanol / 5 h / Heating

4: 61 percent / aq. HCl, NaNO₂ / Ambient temperature

5: 52 percent / dimethylformamide / 3 h / Heating

6: 64 percent / H₂ / 10percent Pd/C / ethyl acetate / 5 h / 2700.2 Torr / Ambient temperature

7: 61 percent / n-BuONa / 8 h / Heating

8: 93 percent / 35percent aq. NaOH / methanol / 72 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; toluene-4-sulfonic acid; acetic acid; sodium butanolate; sodium nitrite; palladium on activated charcoal; In methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570330643