4-[2-(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-yl)-ethyl]-benzoic acid butyl ester

Base Information

Chemical Name:4-[2-(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-yl)-ethyl]-benzoic acid butyl ester
CAS No.:187242-95-1
Molecular Formula:C₂₀H₂₃N₅O₂
Molecular Weight:365.435
Hs Code.:

Synonyms:4-[2-(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-yl)-ethyl]-benzoic acid butyl ester

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Chemical Property of 4-[2-(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-yl)-ethyl]-benzoic acid butyl ester

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Technology Process of 4-[2-(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-yl)-ethyl]-benzoic acid butyl ester

There total 7 articles about 4-[2-(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-yl)-ethyl]-benzoic acid butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 50-01-1
guanidine hydrochloride

: 187242-94-0
4-[2-(5-Amino-6-cyano-pyridin-2-yl)-ethyl]-benzoic acid methyl ester

: 71-36-3
butan-1-ol

: 187242-95-1
4-[2-(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-yl)-ethyl]-benzoic acid butyl ester

Guidance literature:: With sodium butanolate; for 8h; Heating;
DOI:10.1002/jhet.5570330643

Reference yield:

: 187242-82-6
(E)-4-(3-oxobut-1-en-1-yl)benzoic acid

: 187242-95-1
4-[2-(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-yl)-ethyl]-benzoic acid butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 62 percent / p-toluenesulphonic acid / 7 h / Heating

2: 53 percent / H₂ / 10percent Pd/C / ethyl acetate / 3 h / 1500.1 Torr / Ambient temperature

3: 72 percent / AcOH / ethanol / 5 h / Heating

4: 61 percent / aq. HCl, NaNO₂ / Ambient temperature

5: 52 percent / dimethylformamide / 3 h / Heating

6: 64 percent / H₂ / 10percent Pd/C / ethyl acetate / 5 h / 2700.2 Torr / Ambient temperature

7: 61 percent / n-BuONa / 8 h / Heating

With hydrogenchloride; hydrogen; toluene-4-sulfonic acid; acetic acid; sodium butanolate; sodium nitrite; palladium on activated charcoal; In ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570330643

Reference yield:

: 1025940-85-5
4-((1E,4E)-5-Dimethylamino-3-oxo-penta-1,4-dienyl)-benzoic acid methyl ester

: 187242-95-1
4-[2-(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-yl)-ethyl]-benzoic acid butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 53 percent / H₂ / 10percent Pd/C / ethyl acetate / 3 h / 1500.1 Torr / Ambient temperature

2: 72 percent / AcOH / ethanol / 5 h / Heating

3: 61 percent / aq. HCl, NaNO₂ / Ambient temperature

4: 52 percent / dimethylformamide / 3 h / Heating

5: 64 percent / H₂ / 10percent Pd/C / ethyl acetate / 5 h / 2700.2 Torr / Ambient temperature

6: 61 percent / n-BuONa / 8 h / Heating

With hydrogenchloride; hydrogen; acetic acid; sodium butanolate; sodium nitrite; palladium on activated charcoal; In ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570330643