[2-(4-Chlorophenyl)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]acetic acid

Base Information

Chemical Name:[2-(4-Chlorophenyl)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]acetic acid
CAS No.:88460-54-2
Molecular Formula:C₁₆H₁₂ClNO₃
Molecular Weight:301.729
Hs Code.:
DSSTox Substance ID:DTXSID80564337

Synonyms:88460-54-2;SCHEMBL10558214;DTXSID80564337;[2-(4-Chlorophenyl)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]acetic acid

Suppliers and Price of [2-(4-Chlorophenyl)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of [2-(4-Chlorophenyl)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]acetic acid

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:301.0505709
Heavy Atom Count:21
Complexity:420

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(N(C2=O)C3=CC=C(C=C3)Cl)CC(=O)O

Technology Process of [2-(4-Chlorophenyl)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]acetic acid

There total 4 articles about [2-(4-Chlorophenyl)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88460-65-5
Ethyl 3-oxo-2(4-chlorophenyl)isoindoline-1-acetate

: 88460-54-2
2,3-Dihydro-3-oxo-2-(p-chlorophenyl)-1H-isoindole-1-acetic Acid

Guidance literature:: With potassium carbonate; In methanol; water; Yield given;
DOI:10.1248/cpb.38.3024

Reference yield:

: 37896-11-0
2,3-Dihydro-3-hydroxy-2-(p-chlorophenyl)-1H-isoindol-1-one

: 88460-54-2
2,3-Dihydro-3-oxo-2-(p-chlorophenyl)-1H-isoindole-1-acetic Acid

Guidance literature:: Multi-step reaction with 2 steps

1: toluene

2: K₂CO₃ / methanol; H₂O

With potassium carbonate; In methanol; water; toluene;
DOI:10.1248/cpb.38.3024

Reference yield:

: 7386-21-2
N-(4-chlorophenyl)phthalimide

: 88460-54-2
2,3-Dihydro-3-oxo-2-(p-chlorophenyl)-1H-isoindole-1-acetic Acid

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / NaBH₄ / methanol; tetrahydrofuran

2: toluene

3: K₂CO₃ / methanol; H₂O

With sodium tetrahydroborate; potassium carbonate; In tetrahydrofuran; methanol; water; toluene;
DOI:10.1248/cpb.38.3024