8-(Bromomethyl)-5-fluoroquinoline

Base Information

Chemical Name:8-(Bromomethyl)-5-fluoroquinoline
CAS No.:88474-21-9
Molecular Formula:C₁₀H₇BrFN
Molecular Weight:240.075
Hs Code.:
DSSTox Substance ID:DTXSID70522380
Wikidata:Q82387589
Mol file:88474-21-9.mol

Synonyms:8-(bromomethyl)-5-fluoroquinoline;88474-21-9;Quinoline, 8-(bromomethyl)-5-fluoro-;SCHEMBL2563593;5-fluoro-8-bromomethylquinoline;DTXSID70522380;AKOS000131584;EN300-36107;G45324;Z330915018

Suppliers and Price of 8-(Bromomethyl)-5-fluoroquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
8-(BROMOMETHYL)-5-FLUOROQUINOLINE 95.00%
1G
$ 925.31

American Custom Chemicals Corporation
8-(BROMOMETHYL)-5-FLUOROQUINOLINE 95.00%
5G
$ 1759.28

American Custom Chemicals Corporation
8-(BROMOMETHYL)-5-FLUOROQUINOLINE 95.00%
2.5G
$ 1363.65

Alichem
8-(Bromomethyl)-5-fluoroquinoline
25g
$ 4180.80

Alichem
8-(Bromomethyl)-5-fluoroquinoline
10g
$ 2580.84

AK Scientific
8-(Bromomethyl)-5-fluoroquinoline
2.5g
$ 1116.00

AK Scientific
8-(Bromomethyl)-5-fluoroquinoline
100mg
$ 240.00

Total 3 raw suppliers

Chemical Property of 8-(Bromomethyl)-5-fluoroquinoline

Chemical Property:

Melting Point:94-95 °C(Solv: ethanol (64-17-5))
Boiling Point:326.8±27.0 °C(Predicted)
PKA:2.87±0.29(Predicted)
PSA：12.89000
Density:1.595±0.06 g/cm3(Predicted)
LogP:3.26880
XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:238.97459
Heavy Atom Count:13
Complexity:176

Purity/Quality:: 8-(BROMOMETHYL)-5-FLUOROQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC2=C(C=CC(=C2N=C1)CBr)F

Technology Process of 8-(Bromomethyl)-5-fluoroquinoline

There total 2 articles about 8-(Bromomethyl)-5-fluoroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 88474-18-4
5-fluoro-8-methylquinoline

: 88474-21-9
5-fluoro-8-(bromomethyl)quinoline

Guidance literature:: With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 4h; Irradiation;
DOI:10.1007/BF00505763

Reference yield:

: 50358-40-2
8-methylquinolin-5-ylamine

: 88474-21-9
5-fluoro-8-(bromomethyl)quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: NaNO₂/HBF₄ / 1.)0-8 deg C, 15 min 2.)80-90 deg C, 6 h

2: 43 percent / NBS/benzoyl peroxide / CCl₄ / 4 h / Irradiation

With N-Bromosuccinimide; tetrafluoroboric acid; sodium nitrite; dibenzoyl peroxide; In tetrachloromethane;
DOI:10.1007/BF00505763