5-(Benzyloxy)-8-bromo-2-methyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:5-(Benzyloxy)-8-bromo-2-methyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:88493-70-3
Molecular Formula:C17H18BrNO
Molecular Weight:332.23500
Hs Code.:
DSSTox Substance ID:DTXSID20556453
Wikidata:Q82438007

Synonyms:88493-70-3;5-(Benzyloxy)-8-bromo-2-methyl-1,2,3,4-tetrahydroisoquinoline;DTXSID20556453

Suppliers and Price of 5-(Benzyloxy)-8-bromo-2-methyl-1,2,3,4-tetrahydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 5-(Benzyloxy)-8-bromo-2-methyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

PSA：12.47000
LogP:3.95390
XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:331.05718
Heavy Atom Count:20
Complexity:305

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCC2=C(C=CC(=C2C1)Br)OCC3=CC=CC=C3

Technology Process of 5-(Benzyloxy)-8-bromo-2-methyl-1,2,3,4-tetrahydroisoquinoline

There total 3 articles about 5-(Benzyloxy)-8-bromo-2-methyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 88493-69-0
5-benzyloxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

: 88493-70-3
5-benzyloxy-8-bromo-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With bromine; In chloroform; for 2h;
DOI:10.1248/cpb.36.1627

Reference yield:

: 14097-42-8
5-Hydroxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

: 88493-70-3
5-benzyloxy-8-bromo-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, r.t., 1 h ; 2.) 70-80 deg C, 2 h

2: 44 percent / Br₂ / CHCl₃ / 2 h

With bromine; sodium hydride; In chloroform;
DOI:10.1248/cpb.36.1627

Reference yield:

: 100-44-7
benzyl chloride

: 88493-70-3
5-benzyloxy-8-bromo-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, r.t., 1 h ; 2.) 70-80 deg C, 2 h

2: 44 percent / Br₂ / CHCl₃ / 2 h

With bromine; sodium hydride; In chloroform;
DOI:10.1248/cpb.36.1627