1,2,3,4-tetrahydro-2-methyl-5-Isoquinolinol

Base Information

• Chemical Name: 1,2,3,4-tetrahydro-2-methyl-5-Isoquinolinol
• CAS No.: 14097-42-8
• Molecular Formula: C10H13NO
• Molecular Weight: 163.219
• Mol file: 14097-42-8.mol

Synonyms:2-methyl-1,2,3,4-tetrahydro-isoquinolin-5-ol;5-hydroxy-2-methyl-1,2,3,4-tetrahydroisoquinoline;5-ISOQUINOLINOL,1,2,3,4-TETRAHYDRO-2-METHYL-;2-Methyl-1,2,3,4-tetrahydro-isochinolin-5-ol;1,2,3,4-tetrahydro-2-methyl-5-Isoquinolinol;

Chemical Property of 1,2,3,4-tetrahydro-2-methyl-5-Isoquinolinol

Chemical Property:

• Melting Point: 187 °C
• Boiling Point: 271.0±40.0 °C(Predicted)
• PKA: 8.17±0.20(Predicted)
• PSA: 23.47000
• Density: 1.119±0.06 g/cm3(Predicted)
• LogP: 1.31800
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

96% ^*data from raw suppliers

2-Methyl-1,2,3,4-tetrahydroisoquinolin-5-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,3,4-tetrahydro-2-methyl-5-Isoquinolinol

There total 9 articles about 1,2,3,4-tetrahydro-2-methyl-5-Isoquinolinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.3%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1,2,3,4-tetrahydro-5-hydroxy-isoquinoline (102877-50-9) → 5-Hydroxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (14097-42-8)

Guidance literature:

formaldehyd; 1,2,3,4-tetrahydro-5-hydroxy-isoquinoline; In methanol; at 25 ℃; for 0.166667h;

With sodium cyanoborohydride; In methanol; at 25 ℃; for 0.5h;

Reference yield:

→ 1,2,3,4-tetrahydroisoquinoline (91-21-4) + 5-Hydroxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (14097-42-8)

Guidance literature:

Reference yield:

5-hydroxy-2-methylisoquinolin-2-ium iodide (20189-73-5) → 5-Hydroxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (14097-42-8)

Guidance literature:

With methanol; sodium borate; water;

upstream raw materials:

5-amino-2-methyl-1,2,3,4-tetrahydroisoquinoline

5-hydroxy-2-methylisoquinolin-2-ium iodide

2-methyl-5-nitro-1,2,3,4-tetrahydro-isoquinoline

5-hydroxyisoquinoline

Downstream raw materials:

5-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline

5-benzyloxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

5-benzyloxy-8-bromo-2-methyl-1,2,3,4-tetrahydroisoquinoline