Methyl 3-[(benzyloxy)amino]-2,2-dimethylpropanoate

Base Information

Chemical Name:Methyl 3-[(benzyloxy)amino]-2,2-dimethylpropanoate
CAS No.:88517-39-9
Molecular Formula:C13H19NO3
Molecular Weight:237.299
Hs Code.:
DSSTox Substance ID:DTXSID00525566
Wikidata:Q82393264

Synonyms:methyl 3-[(benzyloxy)amino]-2,2-dimethylpropanoate;88517-39-9;SCHEMBL11037169;DTXSID00525566;AKOS018181031;2,2-dimethyl-3-(phenylmethoxyamino)-propionic acid methyl ester

Suppliers and Price of Methyl 3-[(benzyloxy)amino]-2,2-dimethylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 3-[(benzyloxy)amino]-2,2-dimethylpropanoate

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:237.13649347
Heavy Atom Count:17
Complexity:235

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(CNOCC1=CC=CC=C1)C(=O)OC

Technology Process of Methyl 3-[(benzyloxy)amino]-2,2-dimethylpropanoate

There total 2 articles about Methyl 3-[(benzyloxy)amino]-2,2-dimethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 31469-15-5
1-methoxy-2-methyl-1-trimethylsiloxy-1-propene

: 72399-18-9
formaldehyde O-benzyloxime

: 88517-39-9
methyl 3-(N-benzyloxyamino)-2,2-dimethylpropionate

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; for 5h; Ambient temperature;
DOI:10.1016/S0040-4039(00)86233-4

Reference yield:

: 622-33-3
N-benzyloxyamine

: 88517-39-9
methyl 3-(N-benzyloxyamino)-2,2-dimethylpropionate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / 37.5percent NaOH / H₂O; benzene / 1 h / Ambient temperature

2: 89 percent / trimethylsilyl triflate / CH₂Cl₂ / 5 h / Ambient temperature

With sodium hydroxide; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; water; benzene;
DOI:10.1248/cpb.37.1179