Methyl 3-[(benzyloxy)amino]-2,2-dimethylbutanoate

Base Information

Chemical Name:Methyl 3-[(benzyloxy)amino]-2,2-dimethylbutanoate
CAS No.:88517-46-8
Molecular Formula:C14H21NO3
Molecular Weight:251.326
Hs Code.:
DSSTox Substance ID:DTXSID20525568

Synonyms:88517-46-8;Methyl 3-[(benzyloxy)amino]-2,2-dimethylbutanoate;DTXSID20525568

Suppliers and Price of Methyl 3-[(benzyloxy)amino]-2,2-dimethylbutanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 3-[(benzyloxy)amino]-2,2-dimethylbutanoate

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:251.15214353
Heavy Atom Count:18
Complexity:260

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(C)(C)C(=O)OC)NOCC1=CC=CC=C1

Technology Process of Methyl 3-[(benzyloxy)amino]-2,2-dimethylbutanoate

There total 3 articles about Methyl 3-[(benzyloxy)amino]-2,2-dimethylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 31469-15-5
1-methoxy-2-methyl-1-trimethylsiloxy-1-propene

: 91078-04-5
2-Benzyloxy-2-aza-spiro[3.4]octan-1-one

: 88517-46-8
3-Benzyloxyamino-2,2-dimethyl-butyric acid methyl ester

Guidance literature:: trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 30 - 35 ℃; for 18h;
DOI:10.1248/cpb.37.1179

Reference yield:

: 622-33-3
N-benzyloxyamine

: 88517-46-8
3-Benzyloxyamino-2,2-dimethyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / 37.5percent NaOH / H₂O; benzene / 1 h / Ambient temperature

2: 49 percent / LDA / tetrahydrofuran / 2 h / -78 °C

3: 52 percent / trimethylsilyl triflate / acetonitrile / 18 h / 30 - 35 °C

With sodium hydroxide; lithium diisopropyl amide; trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; water; acetonitrile; benzene;
DOI:10.1248/cpb.37.1179

Reference yield:

: 72399-18-9
formaldehyde O-benzyloxime

: 88517-46-8
3-Benzyloxyamino-2,2-dimethyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 49 percent / LDA / tetrahydrofuran / 2 h / -78 °C

2: 52 percent / trimethylsilyl triflate / acetonitrile / 18 h / 30 - 35 °C

With lithium diisopropyl amide; trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; acetonitrile;
DOI:10.1248/cpb.37.1179