1-Benzyl-3-(3-hydroxypropyl)piperazine-2,5-dione

Base Information

Chemical Name:1-Benzyl-3-(3-hydroxypropyl)piperazine-2,5-dione
CAS No.:88521-58-8
Molecular Formula:C14H18N2O3
Molecular Weight:262.309
Hs Code.:
DSSTox Substance ID:DTXSID40523086

Synonyms:88521-58-8;1-BENZYL-3-(3-HYDROXYPROPYL)PIPERAZINE-2,5-DIONE;DTXSID40523086

Suppliers and Price of 1-Benzyl-3-(3-hydroxypropyl)piperazine-2,5-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1-Benzyl-3-(3-hydroxypropyl)piperazine-2,5-dione

Chemical Property:

XLogP3:0.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:262.13174244
Heavy Atom Count:19
Complexity:327

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(=O)NC(C(=O)N1CC2=CC=CC=C2)CCCO

Technology Process of 1-Benzyl-3-(3-hydroxypropyl)piperazine-2,5-dione

There total 6 articles about 1-Benzyl-3-(3-hydroxypropyl)piperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 88521-40-8
1-benzyl-3-(3-hydroxypropylidene)-2,5-piperazinedione

: 88521-58-8
1-benzyl-3-(3-hydroxypropyl)-2,5-piperazinedione

Guidance literature:: With hydrogen; 10% palladium on active carbon; In methanol; for 0.333333h; Ambient temperature;
DOI:10.1246/bcsj.56.2652

Reference yield: 64.0%

: 344873-93-4
4'-benzyl-3-bromospiro-3',6'-dione

: 88521-58-8
1-benzyl-3-(3-hydroxypropyl)-2,5-piperazinedione

Guidance literature:: With hydrogen; 10% palladium on active carbon; In methanol; for 24h; Ambient temperature;
DOI:10.1246/bcsj.56.2652

Reference yield:

: 5965-53-7
diethyl 2-ketoglutarate

: 88521-58-8
1-benzyl-3-(3-hydroxypropyl)-2,5-piperazinedione

Guidance literature:: Multi-step reaction with 5 steps

1: 57 percent / POCl₃, conc. H₂SO₄ / benzene / Heating

2: 1.) KI / 1.) ethanol, 2.) ethanol, RT, 2 h

3: 60 percent / LiAlH₄ / tetrahydrofuran / -10 °C

4: N-bromosuccinimide (NBS) / CHCl₃ / 0.17 h / Ambient temperature

5: 64 percent / H₂ / 10percentPd/C / methanol / 24 h / Ambient temperature

With N-Bromosuccinimide; lithium aluminium tetrahydride; sulfuric acid; hydrogen; potassium iodide; trichlorophosphate; 10% palladium on active carbon; In tetrahydrofuran; methanol; chloroform; benzene;
DOI:10.1246/bcsj.56.2652