D-Proline, 2-methylalanyl-L-phenylalanyl-, methyl ester

Base Information

Chemical Name:D-Proline, 2-methylalanyl-L-phenylalanyl-, methyl ester
CAS No.:88568-96-1
Molecular Formula:C19H27N3O4
Molecular Weight:361.441
Hs Code.:
DSSTox Substance ID:DTXSID101206282

Synonyms:DTXSID101206282;D-Proline, 2-methylalanyl-L-phenylalanyl-, methyl ester;88568-96-1

Suppliers and Price of D-Proline, 2-methylalanyl-L-phenylalanyl-, methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of D-Proline, 2-methylalanyl-L-phenylalanyl-, methyl ester

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:361.20015635
Heavy Atom Count:26
Complexity:529

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C(=O)NC(CC1=CC=CC=C1)C(=O)N2CCCC2C(=O)OC)N
Isomeric SMILES:CC(C)(C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N2CCC[C@@H]2C(=O)OC)N

Technology Process of D-Proline, 2-methylalanyl-L-phenylalanyl-, methyl ester

There total 6 articles about D-Proline, 2-methylalanyl-L-phenylalanyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 2577-48-2,43041-12-9,52183-82-1
D-Pro-OMe

: 88568-96-1
H-Aib-L-Phe-D-Pro-OMe

Guidance literature:: DOI:10.1016/S0040-4039(00)87854-5

Reference yield:

: 152972-11-7
Z-AIB-(L)-Phe-(D)-Pro-OMe

: 88568-96-1
Methyl N-(dimethylglycyl)-(S)-phenylalanyl-(R)-prolinate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 3h; Yield given;
DOI:10.1016/S0040-4020(01)88010-8

Reference yield:

: 152972-10-6
Z-AIB-(L)-Phe-O-(t-Bu)

: 88568-96-1
Methyl N-(dimethylglycyl)-(S)-phenylalanyl-(R)-prolinate

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / TFA / CH₂Cl₂ / 16 h

2: 65 percent / Et₃N, DCC, 1-hydroxybenzotriazole / tetrahydrofuran / 16 h

3: hydrogen / 5percent Pd/C / methanol / 3 h

With hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)88010-8