Ethyl 1-phenyl-1H-pyrazole-4-carboxylate, 97%

Base Information

• Chemical Name: Ethyl 1-phenyl-1H-pyrazole-4-carboxylate, 97%
• CAS No.: 885-94-9
• Molecular Formula: C12H12N2O2
• Molecular Weight: 216.239
• Hs Code.: 2933199090
• Mol file: 885-94-9.mol

Synonyms:1-Phenyl-1H-pyrazol-4-carbonsaeure-aethylester;1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester;Ethyl 1-phenyl-4-pyrazolecarboxylate;1H-Pyrazole-4-carboxylic acid,1-phenyl-,ethyl ester;1-phenyl-4-ethoxycarbonylpyrazole;ethyl 1-phenyl-1H-pyrazole-4-carboxylate;

Chemical Property of Ethyl 1-phenyl-1H-pyrazole-4-carboxylate, 97%

Chemical Property:

• Melting Point: 97-99℃
• Boiling Point: 330.8±15.0 °C(Predicted)
• PKA: -2.50±0.10(Predicted)
• PSA: 44.12000
• Density: 1.15±0.1 g/cm3(Predicted)
• LogP: 2.04900
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

ethyl1-phenyl-1H-pyrazole-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 1-phenyl-1H-pyrazole-4-carboxylate, 97%

There total 25 articles about Ethyl 1-phenyl-1H-pyrazole-4-carboxylate, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-Phenyl-1-butyne (16520-62-0) + 3-(4-formylphenyl)-1,2,3λ5-oxadiazol-3-ylium-5-olate → ethyl 1-phenylpyrazole-4-carboxylate (885-94-9)

Guidance literature:

With copper(ll) sulfate pentahydrate; triethanolamine; ascorbic acid sodium salt; In water; tert-butyl alcohol; at 60 ℃; for 16h;

DOI:10.1002/anie.201305645

Reference yield: 91.0%

4-ethoxycarbonylpyrazole (37622-90-5) + bromobenzene (108-86-1,52753-63-6) → ethyl 1-phenylpyrazole-4-carboxylate (885-94-9)

Guidance literature:

With quebrachitol; copper; caesium carbonate; In water; dimethyl sulfoxide; at 100 ℃; Inert atmosphere; Green chemistry;

DOI:10.1021/acs.joc.9b00997

Reference yield: 90.0%

phenylazo 4-methylphenyl sulfone (26788-89-6) + ethyl 2-((tert-butoxycarbonyloxy)methyl)acrylate → ethyl 1-phenylpyrazole-4-carboxylate (885-94-9)

Guidance literature:

With tributylphosphine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/ol503735c

upstream raw materials:

ethyl 3-(phenylhydrazono)propionate

phenylhydrazine

ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate

ethyl 2-formyl-3-oxopropanoate

Downstream raw materials:

(1-phenyl-1H-pyrazol-4-yl)methanol

4-carboxy-1-phenylpyrazole

ethyl 1-(2-allylphenyl)-1H-pyrazole-4-carboxylate

4-Bromomethyl-1-phenyl-1H-pyrazole

Refernces

• 1、 Dos Santos, Maurício Silva,Ferreira, Byanca Silva,Silva, Rafaela Corrêa,Souto, Bernardo Araújo. "Synthesis of pyrazole-carboxamides and pyrazole-carboxylic acids derivatives: Simple methods to access powerful building blocks". . p. 335 - 343. Retrieved 2021/09/07.
• 2、 -. "NOVEL COMPOUND AS MTOR INHIBITOR AND USE THEREOF". Paragraph 0063; 0096. . Retrieved 2021/03/04.