D-Proline, 1-[N-[N-[7-[2-(2-chloroethyl)-1,3-dioxolan-2-yl]-1-oxo-2-[[(phenylmethoxy )carbonyl]amino]heptyl]-2-methylalanyl]-L-phenylalanyl]-, pentafluorophenyl ester, (R)-

Base Information

Chemical Name:D-Proline, 1-[N-[N-[7-[2-(2-chloroethyl)-1,3-dioxolan-2-yl]-1-oxo-2-[[(phenylmethoxy )carbonyl]amino]heptyl]-2-methylalanyl]-L-phenylalanyl]-, pentafluorophenyl ester, (R)-
CAS No.:88643-27-0
Molecular Formula:C₄₄H₅₀ClF₅N₄O₉
Molecular Weight:909.347
Hs Code.:

D-Proline,
1-[N-[N-[7-[2-(2-chloroethyl)-1,3-dioxolan-2-yl]-1-oxo-2-[[(phenylmethoxy
)carbonyl]amino]heptyl]-2-methylalanyl]-L-phenylalanyl]-,
pentafluorophenyl ester, (R)-

Synonyms:

Suppliers and Price of D-Proline, 1-[N-[N-[7-[2-(2-chloroethyl)-1,3-dioxolan-2-yl]-1-oxo-2-[[(phenylmethoxy )carbonyl]amino]heptyl]-2-methylalanyl]-L-phenylalanyl]-, pentafluorophenyl ester, (R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of D-Proline, 1-[N-[N-[7-[2-(2-chloroethyl)-1,3-dioxolan-2-yl]-1-oxo-2-[[(phenylmethoxy )carbonyl]amino]heptyl]-2-methylalanyl]-L-phenylalanyl]-, pentafluorophenyl ester, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of D-Proline, 1-[N-[N-[7-[2-(2-chloroethyl)-1,3-dioxolan-2-yl]-1-oxo-2-[[(phenylmethoxy )carbonyl]amino]heptyl]-2-methylalanyl]-L-phenylalanyl]-, pentafluorophenyl ester, (R)-

There total 18 articles about D-Proline, 1-[N-[N-[7-[2-(2-chloroethyl)-1,3-dioxolan-2-yl]-1-oxo-2-[[(phenylmethoxy )carbonyl]amino]heptyl]-2-methylalanyl]-L-phenylalanyl]-, pentafluorophenyl ester, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50628-92-7
ethyl 6-oxo-7-octenoate

: 88568-93-8,88643-27-0
(R)-1-[(S)-2-(2-{(S)-2-Benzyloxycarbonylamino-7-[2-(2-chloro-ethyl)-[1,3]dioxolan-2-yl]-heptanoylamino}-2-methyl-propionylamino)-3-phenyl-propionyl]-pyrrolidine-2-carboxylic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) HCl / 2.) Ethylenglykol

2: Red-Al

3: Pyridinium-chlorochromat

4: 84 percent / Lithium-diisopropylamid

5: H₂ / Pd

7: NaOH

8: DCCD

9: NaOH

10: DCCD

With hydrogenchloride; sodium hydroxide; hydrogen; dicyclohexyl-carbodiimide; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; lithium diisopropyl amide; palladium;
DOI:10.1016/S0040-4039(00)88171-X

Reference yield:

: 50628-92-7
ethyl 6-oxo-7-octenoate

: 88568-93-8,88643-27-0
(R)-1-[(S)-2-(2-{(R)-2-Benzyloxycarbonylamino-7-[2-(2-chloro-ethyl)-[1,3]dioxolan-2-yl]-heptanoylamino}-2-methyl-propionylamino)-3-phenyl-propionyl]-pyrrolidine-2-carboxylic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) HCl / 2.) Ethylenglykol

2: Red-Al

3: Pyridinium-chlorochromat

4: 84 percent / Lithium-diisopropylamid

5: H₂ / Pd

7: NaOH

8: DCCD

9: NaOH

10: DCCD

With hydrogenchloride; sodium hydroxide; hydrogen; dicyclohexyl-carbodiimide; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; lithium diisopropyl amide; palladium;
DOI:10.1016/S0040-4039(00)88171-X

Reference yield:

: 41571-12-4
5-[2-(2-Chloro-ethyl)-[1,3]dioxolan-2-yl]-pentan-1-ol

: 88568-93-8,88643-27-0
(R)-1-[(S)-2-(2-{(R)-2-Benzyloxycarbonylamino-7-[2-(2-chloro-ethyl)-[1,3]dioxolan-2-yl]-heptanoylamino}-2-methyl-propionylamino)-3-phenyl-propionyl]-pyrrolidine-2-carboxylic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: Pyridinium-chlorochromat

2: 84 percent / Lithium-diisopropylamid

3: H₂ / Pd

5: NaOH

6: DCCD

7: NaOH

8: DCCD

With sodium hydroxide; hydrogen; dicyclohexyl-carbodiimide; pyridinium chlorochromate; lithium diisopropyl amide; palladium;
DOI:10.1016/S0040-4039(00)88171-X