Phosphine, [(1,1-dimethylethyl)dimethylsilyl][2,4,6-tris(1,1-dimethylethyl)phenyl]-, lithium salt

Base Information

Chemical Name:Phosphine, [(1,1-dimethylethyl)dimethylsilyl][2,4,6-tris(1,1-dimethylethyl)phenyl]-, lithium salt
CAS No.:88721-97-5
Molecular Formula:C24H45PSi.Li
Molecular Weight:398.614
Hs Code.:

Synonyms:

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Chemical Property of Phosphine, [(1,1-dimethylethyl)dimethylsilyl][2,4,6-tris(1,1-dimethylethyl)phenyl]-, lithium salt

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of Phosphine, [(1,1-dimethylethyl)dimethylsilyl][2,4,6-tris(1,1-dimethylethyl)phenyl]-, lithium salt

There total 1 articles about Phosphine, [(1,1-dimethylethyl)dimethylsilyl][2,4,6-tris(1,1-dimethylethyl)phenyl]-, lithium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83115-12-2
(2,4,6-tri-tert-butylphenyl)phosphine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 88721-97-5
lithium (t-butyldimethylsilyl)(2,4,6-tri-t-butylphenyl)phosphide

Guidance literature:: With lithiation;
DOI:10.1002/hlca.19940770135

Reference yield: 87.1%

: chloromethyl(1,5-cyclooctadiene)palladium(II)

: 487060-99-1
2-methyl-2-(2,4,6-tri-isopropylphenylthio)propanal

: 88721-97-5
lithium (t-butyldimethylsilyl)(2,4,6-tri-t-butylphenyl)phosphide

: 487061-00-7
[((2,4,6-(i-Pr)3C₆H₂)SCMe₂CH=P(2,4,6-tri-tert-butylphenyl))PdMeCl]

Guidance literature:: In tetrahydrofuran; dichloromethane; byproducts: cyclooctadiene, (t-Bu)3C6H2PH2, t-BuMe2SiOLi; (Ar); standard Schlenk technique; soln. of aldehyde in THF was added dropwise to soln. of (t-Bu)3C6H2P(Li)SiMe2(t-Bu) in THF at -78°C; soln. stirred for 30 min at -78°C; warmed to room temp.; Me4SiCl was added; evapd.; coevapd. (hexane);; soln. of Pd complex in CH2Cl2 added; soln. was stirred at room temp. for10 h; evapd.; residue dissolved in hexane; chromd. (silica gel, hexane; CH2Cl2); evapd.; residue triturated with hexane (-30°C); elem. a nal.;
DOI:10.1021/om020631x

Reference yield: 86.7%

: chloromethyl(1,5-cyclooctadiene)palladium(II)

: 79428-47-0
α-tert-butylthioacetaldehyde

: 88721-97-5
lithium (t-butyldimethylsilyl)(2,4,6-tri-t-butylphenyl)phosphide

: 487061-14-3
[((tert-butyl)SCH₂CH=P(2,4,6-tri-tert-butylphenyl))PdMeCl]

Guidance literature:: In tetrahydrofuran; dichloromethane; byproducts: cyclooctadiene, (t-Bu)3C6H2PH2, t-BuMe2SiOLi; (Ar); standard Schlenk technique; soln. of aldehyde in THF was added dropwise to soln. of (t-Bu)3C6H2P(Li)SiMe2(t-Bu) in THF at -78°C; soln. stirred for 30 min at -78°C; warmed to room temp. and stirredfor 1 h; Me4SiCl was added; evapd.;; CH2Cl2 added; Pd complex added; soln. was stirred at room temp. for 12 h; evapd.; residue chromd. (silica gel, hexane; toluene; CH2Cl2); evapd.;crystd. (CH3CN); elem. anal.;
DOI:10.1021/om020631x