1-Amino-5-methyl-5-phenylpyrrolidin-2-one

Base Information

• Chemical Name: 1-Amino-5-methyl-5-phenylpyrrolidin-2-one
• CAS No.: 88730-06-7
• Molecular Formula: C11H14N2O
• Molecular Weight: 190.245
• DSSTox Substance ID: DTXSID00539784
• Mol file: 88730-06-7.mol

Synonyms:1-Amino-5-methyl-5-phenylpyrrolidin-2-one;88730-06-7;DTXSID00539784

Chemical Property of 1-Amino-5-methyl-5-phenylpyrrolidin-2-one

Chemical Property:

• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 190.110613074
• Heavy Atom Count: 14
• Complexity: 235

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CCC(=O)N1N)C2=CC=CC=C2

Technology Process of 1-Amino-5-methyl-5-phenylpyrrolidin-2-one

There total 2 articles about 1-Amino-5-methyl-5-phenylpyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Hydroxy-4-phenyl-pentanoic acid hydrazide (88730-04-5) → 1-Amino-5-methyl-5-phenyl-pyrrolidin-2-one (88730-06-7)

Guidance literature:

With sulfuric acid; In dichloromethane; Yield given;

DOI:10.1021/ja00317a068

Reference yield:

5-methyl-5-phenyl-dihydro-furan-2-one (7210-42-6,21303-80-0,69854-29-1,88314-79-8) → 1-Amino-5-methyl-5-phenyl-pyrrolidin-2-one (88730-06-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 100percent hydrazine hydrate / ethanol / Heating

2: concentrated sulfuric acid / CH₂Cl₂

With sulfuric acid; hydrazine hydrate; In ethanol; dichloromethane;

DOI:10.1021/ja00317a068

Reference yield:

1-Amino-5-methyl-5-phenyl-pyrrolidin-2-one (88730-06-7) → 5-methyl-5-phenyl-dihydro-furan-2-one (7210-42-6,21303-80-0,69854-29-1,88314-79-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tert-butyl hypochlorite, 2,6-lutidine / diethyl ether

2: diethyl ether

With 2,6-dimethylpyridine; tert-butylhypochlorite; In diethyl ether;

DOI:10.1021/ja00317a068

upstream raw materials:

4-Hydroxy-4-phenyl-pentanoic acid hydrazide

5-methyl-5-phenyl-dihydro-furan-2-one

Downstream raw materials:

C₁₁H₁₂N₂O

4-Hydroxy-4-phenyl-pentanoic acid dimethylamide

4-Methoxy-4-phenyl-pentanoic acid methyl ester

5-methyl-5-phenyl-dihydro-furan-2-one