4-Hydroxy-4-phenyl-pentanoic acid hydrazide

Base Information

• Chemical Name: 4-Hydroxy-4-phenyl-pentanoic acid hydrazide
• CAS No.: 88730-04-5
• Molecular Formula: C₁₁H₁₆N₂O₂
• Molecular Weight: 208.26
• Mol file: 88730-04-5.mol

Synonyms:4-Hydroxy-4-phenyl-pentanoic acid hydrazide

Chemical Property of 4-Hydroxy-4-phenyl-pentanoic acid hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 4-Hydroxy-4-phenyl-pentanoic acid hydrazide

There total 1 articles about 4-Hydroxy-4-phenyl-pentanoic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methyl-5-phenyl-dihydro-furan-2-one (7210-42-6,21303-80-0,69854-29-1,88314-79-8) → 4-Hydroxy-4-phenyl-pentanoic acid hydrazide (88730-04-5)

Guidance literature:

With hydrazine hydrate; In ethanol; Heating;

DOI:10.1021/ja00317a068

Reference yield:

4-Hydroxy-4-phenyl-pentanoic acid hydrazide (88730-04-5) → 5-methyl-5-phenyl-dihydro-furan-2-one (7210-42-6,21303-80-0,69854-29-1,88314-79-8)

Guidance literature:

Multi-step reaction with 3 steps

1: concentrated sulfuric acid / CH₂Cl₂

2: tert-butyl hypochlorite, 2,6-lutidine / diethyl ether

3: diethyl ether

With 2,6-dimethylpyridine; tert-butylhypochlorite; sulfuric acid; In diethyl ether; dichloromethane;

DOI:10.1021/ja00317a068

Reference yield:

4-Hydroxy-4-phenyl-pentanoic acid hydrazide (88730-04-5) → 1-Amino-5-methyl-5-phenyl-pyrrolidin-2-one (88730-06-7)

Guidance literature:

With sulfuric acid; In dichloromethane; Yield given;

DOI:10.1021/ja00317a068

upstream raw materials:

5-methyl-5-phenyl-dihydro-furan-2-one

Downstream raw materials:

1-Amino-5-methyl-5-phenyl-pyrrolidin-2-one

C₁₁H₁₂N₂O

4-Hydroxy-4-phenyl-pentanoic acid dimethylamide

4-Methoxy-4-phenyl-pentanoic acid methyl ester