4,5-DICHLORO-2-NITROPHENOL

Base Information

• Chemical Name: 4,5-DICHLORO-2-NITROPHENOL
• CAS No.: 39224-65-2
• Molecular Formula: C6H3 Cl2 N O3
• Molecular Weight: 208.001
• Hs Code.: 2908999090
• Mol file: 39224-65-2.mol

Synonyms:4,5-Dichloro-2-nitrophenol

Chemical Property of 4,5-DICHLORO-2-NITROPHENOL

Chemical Property:

• Vapor Pressure: 0.00332mmHg at 25°C
• Melting Point: 82-82.5℃
• Boiling Point: 274°Cat760mmHg
• PKA: 5.31±0.27(Predicted)
• Flash Point: 119.5°C
• PSA: 66.05000
• Density: 1.682g/cm³
• LogP: 3.13040
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

4,5-Dichloro-2-nitrophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4,5-Dichloro-2-nitrophenol is used in the synthesis of dimethylpropanthioates as CETP inhibitors. Also used in the improved synthesis of hydroxyindoles.

Technology Process of 4,5-DICHLORO-2-NITROPHENOL

There total 6 articles about 4,5-DICHLORO-2-NITROPHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1,2-dichloro-4,5-dinitrobenzene (6306-39-4) → 2-nitro-4,5-dichlorophenol (39224-65-2)

Guidance literature:

With sodium hydroxide; for 5h; Reflux;

DOI:10.5935/0103-5053.20130148

Reference yield: 57.0%

3,4-dichloronitrobenzene (99-54-7) → 2-chloro-4-nitrophenol (619-08-9) + 2-nitro-4,5-dichlorophenol (39224-65-2) + 2,3-dichloro-6-nitrophenol (28165-60-8)

Guidance literature:

With tert.-butylhydroperoxide; potassium tert-butylate; In ammonia; at -33 ℃;

DOI:10.1021/jo970726m

Reference yield: 42.0%

3,4-dichlorophenol (95-77-2) → 2-nitro-4,5-dichlorophenol (39224-65-2)

Guidance literature:

With sulfuric acid; nitric acid; In dichloromethane; at -15 - 0 ℃; for 1.33h;

upstream raw materials:

1,2-dichloro-4,5-dinitrobenzene

3,4-dichlorophenol

3,4-dichloronitrobenzene

2,4,5-Trichloronitrobenzene

Downstream raw materials:

2-amino-4,5-dichlorophenol

4-chloro-6-nitro-resorcinol

1-benzyloxy-4,5-dichloro-2-nitrobenzene

N-(4,5-dichloro-2-mercaptophenyl)-1-isopentylcyclohexanecarboxamide

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